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Table of Contents
Vol. 70, No. 4, 2002/2003
Issue release date: April 2003
Section title: Original Paper
Pathobiology 2002–03;70:197–203
(DOI:10.1159/000069329)

Altered Expression of Cardiac Ankyrin Repeat Protein and Its Homologue, Ankyrin Repeat Protein with PEST and Proline-Rich Region, in Atrophic Muscles in Amyotrophic Lateral Sclerosis

Nakamura K.a · Nakada C.a · Takeuchi K.d · Osaki M.b · Shomori K.b · Kato S.c · Ohama E.c · Sato K.a · Fukayama M.f · Mori S.e · Ito H.b · Moriyama M.a
aDivision of Molecular Biology, Department of Molecular and Cellular Biology, bDivision of Organ Pathology, Department of Microbiology and Pathology, and cDivision of Neuropathology, Institute of Neurological Science, Tottori University, Yonago, dDepartment of Laboratory Medicine, Research Hospital, and Departments of Pathology, eInstitute of Medical Science, and fGraduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 30, 2002
Accepted: September 16, 2002
Published online: April 11, 2003
Issue release date: April 2003

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: http://www.karger.com/PAT

Abstract

Objectives: Cardiac ankyrin repeat protein, CARP, is a protein that is restrictedly expressed in the heart but barely expressed in skeletal muscles. Since CARP is induced by pressure overload to the heart, it is proposed to be a genetic marker for cardiac hypertrophy. We recently identified a novel protein, ankyrin repeat protein with PEST and proline-rich region (ARPP), which is homologous to CARP and is preferentially expressed in type 1 skeletal muscle fibers (cf. slow fibers). We also found that both ARPP and CARP expression is induced in experimentally denervated skeletal muscles in mice. Based on these findings, we hypothesized that their expression may be induced in skeletal muscles in neurodegenerating disease. This work aimed to determine the expression pattern of ARPP and CARP in amyotrophic lateral sclerosis (ALS). Methods: In this study, we immunohistochemically analyzed the expression of ARPP and CARP in skeletal muscles of 9 ALS cases. Results: We found that CARP was aberrantly expressed in atrophic skeletal muscle fibers in ALS. Although ARPP-positive fibers were randomly scattered in a checkerboard-like pattern in normal skeletal muscle, this pattern was absent in ALS muscles. Furthermore, we also found that ARPP was expressed in fast myosin heavy chain-positive fibers (cf. type 2 fiber). Conclusion: These findings suggest that type-specific expression patterns of ARPP and CARP are altered in skeletal muscles of ALS.

© 2003 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 30, 2002
Accepted: September 16, 2002
Published online: April 11, 2003
Issue release date: April 2003

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: http://www.karger.com/PAT


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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