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Vol. 26, No. 1, 2003
Issue release date: 2003
Section title: Original Paper
Kidney Blood Press Res 2003;26:27–33
(DOI:10.1159/000069761)

Parathyroid Hormone Has a Prosclerotic Effect on Vascular Smooth Muscle Cells

Perkovic V.a,b · Hewitson T.D.a · Kelynack K.J.a · Martic M.a · Tait M.G.a · Becker G.J.a
aDepartment of Nephrology and bDepartment of Medicine, University of Melbourne, The Royal Melbourne Hospital, Melbourne, Australia

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/18/2002
Published online: 4/24/2003
Issue release date: 2003

Number of Print Pages: 7
Number of Figures: 6
Number of Tables: 0

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR

Abstract

Although accelerated atherosclerosis and arteriosclerosis are common in patients with renal failure, the pathogenesis of these changes is poorly understood. Parathyroid hormone (PTH) levels are elevated in renal failure, and have been linked to uraemic vascular changes in some studies. We examined the in vitro effects of increasing doses of the 1–34 fragment of PTH on human aortic vascular smooth muscle cells (VSMCs). Factors examined were: (1) collagen production using tritiated hydroxyproline incorporation and transcription of procollagen α1(I) mRNA; (2) change in the surface area of collagen I lattices; (3) mRNA transcription of the collagen binding protein β1 integrin; (4) proliferation using tritiated thymidine incorporation, and (5) methyl tetrazolium salt conversion to estimate live cell number after 5 days’ exposure to PTH. PTH at a concentration of 200 pmol/l increased total collagen synthesis (188 ± 25% of control, p < 0.01) as well as transcription of procollagen α1(I) mRNA (136 ± 11% of control, p < 0.005). PTH also increased reorganisation of collagen I lattices (surface area 47 ± 8% of well for control vs. 35.7 ± 2.5 and 34.3 ± 3.0% for PTH 100 and 200 pmol/l, respectively, p = 0.02) and upregulated β1 integrin mRNA expression (160 ± 20% of control at PTH concentration of 200 pmol/l, p < 0.05). PTH had no effect on VSMC proliferation or number at doses up to 200 pmol/l. In conclusion, PTH increases production and reorganisation of collagen by VSMCs in vitro. It is possible that more aggressive control of hyperparathyroidism in patients with renal failure may help to reduce the burden of cardiovascular disease in this patient population.

© 2003 S. Karger AG, Basel


  

Author Contacts

Dr. Vlado Perkovic
Department of Nephrology
The Royal Melbourne Hospital
Melbourne, Vic. 3050 (Australia)
Tel. +61 403 395395, Fax +61 3 9347 1420, E-Mail vlado-perkovic@mh.org.au

  

Article Information

Accepted: November 18, 2002
Number of Print Pages : 7
Number of Figures : 6, Number of Tables : 0, Number of References : 40

  

Publication Details

Kidney & Blood Pressure Research
formerly: Renal Physiology and BiochemistryFounded 1978 by G.M. Berlyne and S. Thomas
Official Journal of the Gesellschaft für Nephrologie and of the Czech Society of Nephrology

Vol. 26, No. 1, Year 2003 (Cover Date: 2003)

Journal Editor: C. Bauer, Zürich; W.H. Hörl, Vienna; F. Lang, Tübingen; K.H. Rahn, Münster
ISSN: 1420–4096 (print), 1423–0143 (Online)

For additional information: http://www.karger.com/kib


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/18/2002
Published online: 4/24/2003
Issue release date: 2003

Number of Print Pages: 7
Number of Figures: 6
Number of Tables: 0

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR


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