Clinical Utility of Available Methods for Determining Platelet FunctionMcKenzie M.E. · Gurbel P.A. · Levine D.J. · Serebruany V.L.
Sinai Hospital of Baltimore, Baltimore, Md., USA
Determination of platelet function has become increasingly important as new antiplatelet drugs are being developed. Objective means to monitor the pharmacological effects of these agents, in order to maximize efficacy and minimize toxicity, is needed. The available methods for determination of platelet function at the current time are reviewed, including platelet aggregometry, the PFA-100, flow cytometry, platelet contractile force, the rapid platelet function assay, the clot signature analyzer, Sonoclot, and thromboelastography. The principle, advantages, disadvantages, and clinical utility of each method is presented. The uses of the various methods of determining platelet function reported in the literature are summarized, in an effort to provide information regarding the applicability of those different methods.
Dr. Victor L. Serebruany
Center for Thrombosis Research, Sinai Hospital of Baltimore
2401 West Belvedere Avenue, Schapiro Research Building – R 202
Baltimore, MD 21215 (USA)
Tel. +1 410 601 5266, Fax +1 410 601 9061, E-Mail Heartdrug@aol.com
Number of Print Pages : 8
Number of Figures : 0, Number of Tables : 0, Number of References : 61
Cardiology (International Journal of Cardiovascular Medicine, Surgery andPathology)
Founded 1937 as ‘Cardiologia’ by Bruno Kisch and WilhelmLöffler
Vol. 92, No. 4, Year 1999 (Cover Date: Released April 2000)
Journal Editor: Joseph S. Alpert, Tucson, Ariz.
ISSN: 0008–6312 (print), 1421–9751 (Online)
For additional information:http://www.karger.com/journals/crd