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Vol. 26, No. 2, 2003
Issue release date: April 2003
Section title: Original Article · Originalarbeit
Onkologie 2003;26:147–152
(DOI:10.1159/000069835)

Interferon-a2b Reduces Neo-Microvascular Density in the ‘Normal’ Urothelium Adjacent to the Tumor after Transurethral Resection of Superficial Bladder Carcinoma

Giannopoulos A.a · Adamakis I.a · Evangelou K.b · Giannopoulou M.a · Zacharatos P.b · Zsantoulis P.b · Perunovic B.c · Athanasiou A.b · Retalis G.a · Constandinidis C.a · Gorgoulis V.G.b
aDepartment of Urology, School of Medicine, University of Athens, Laiko Hospital, Athens; bMolecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, Greece; cDepartment of Histopathology, University Hospital, Coventry and Warwickshire NHS Trust, Walsgrave Hospital, United Kingdom

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Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: 5/9/2003
Issue release date: April 2003

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 2296-5270 (Print)
eISSN: 2296-5262 (Online)

For additional information: http://www.karger.com/ORT

Abstract

Backround: As angiogenesis represents one of the hallmarks of cancer we investigated whether intravesicaly administered interferon-a (IFN-a2b) reduces neo-angiogenesis in the ‘normal’ urothelium adjacent to the tumor in patients with superficial bladder carcinoma after complete transurethral resection (TUR) of the tumor. Patients and Methods: In the present study 47 patients after TUR of the tumor were examined. 10 patients (group A) received no further treatment (control group); 37 patients (group B) received intravesical treatment with IFN-a2b. The instillations started within 7 days after TUR, were performed weekly for 2 months, twice a month for the next 4 months, and thereafter monthly for 6 more months. Cold cup biopsies were taken before TUR of the transitional cell carcinoma (TCC): from the tumor (T), near tumor (NT) and from normal epithelium (N). Cold cup biopsies ‘near tumor’, were also taken during follow-up cystoscopy (C1, C2, and C3) 2, 6, and 12 months after TUR, respectively. Angiogenesis was estimated by counting the microvessels detected with CD31 immunostaining. Results: Significant differences of microvascular density (MVD) between patients of group A and B appear after TUR (p < 0.005, Kruskal-Wallis and Wilcoxon test). The MVD difference was maximal 6 months after TUR (C2A-C2B, second cystoscopy) and measured at 12.17 microvessels/ mm² (26.2%). Conclusion: Our results show that the intravesical administration of IFN-a2b after TUR significantly decreases the angiogenic potential of the ‘healthy’ urothelium adjacent to the tumor in patients with TCC. This observation could possibly explain, to a certain extent, the mechanism by which IFN-a2b reduces the recurrence rate of primary TCC.

© 2003 S. Karger GmbH, Freiburg


  

Publication Details

Onkologie (International Journal for Cancer Research and Treatment)
Offizielles Organ der Deutschen Gesellschaft für Hämatologie und Onkologie, der Österreichischen Gesellschaft für Hämatologie und Onkologie, der Österreichischen Krebsgesellschaft–Krebsliga unter Fortführung der ‘Österreichischen Zeitung für Onkologie’

Vol. 26, No. 2, Year 2003 (Cover Date: April 2003)

Journal Editor: H.-J. Schmoll, Halle
ISSN: 0378–584X (print), 1423–0240 (Online)

For additional information: http://www.karger.com/onk


Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: 5/9/2003
Issue release date: April 2003

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 2296-5270 (Print)
eISSN: 2296-5262 (Online)

For additional information: http://www.karger.com/ORT


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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