Original Article · Originalarbeit
Interferon-a2b Reduces Neo-Microvascular Density in the ‘Normal’ Urothelium Adjacent to the Tumor after Transurethral Resection of Superficial Bladder CarcinomaGiannopoulos A.a · Adamakis I.a · Evangelou K.b · Giannopoulou M.a · Zacharatos P.b · Zsantoulis P.b · Perunovic B.c · Athanasiou A.b · Retalis G.a · Constandinidis C.a · Gorgoulis V.G.b
aDepartment of Urology, School of Medicine, University of Athens, Laiko Hospital, Athens; bMolecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, Greece; cDepartment of Histopathology, University Hospital, Coventry and Warwickshire NHS Trust, Walsgrave Hospital, United Kingdom
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Backround: As angiogenesis represents one of the hallmarks of cancer we investigated whether intravesicaly administered interferon-a (IFN-a2b) reduces neo-angiogenesis in the ‘normal’ urothelium adjacent to the tumor in patients with superficial bladder carcinoma after complete transurethral resection (TUR) of the tumor. Patients and Methods: In the present study 47 patients after TUR of the tumor were examined. 10 patients (group A) received no further treatment (control group); 37 patients (group B) received intravesical treatment with IFN-a2b. The instillations started within 7 days after TUR, were performed weekly for 2 months, twice a month for the next 4 months, and thereafter monthly for 6 more months. Cold cup biopsies were taken before TUR of the transitional cell carcinoma (TCC): from the tumor (T), near tumor (NT) and from normal epithelium (N). Cold cup biopsies ‘near tumor’, were also taken during follow-up cystoscopy (C1, C2, and C3) 2, 6, and 12 months after TUR, respectively. Angiogenesis was estimated by counting the microvessels detected with CD31 immunostaining. Results: Significant differences of microvascular density (MVD) between patients of group A and B appear after TUR (p < 0.005, Kruskal-Wallis and Wilcoxon test). The MVD difference was maximal 6 months after TUR (C2A-C2B, second cystoscopy) and measured at 12.17 microvessels/ mm² (26.2%). Conclusion: Our results show that the intravesical administration of IFN-a2b after TUR significantly decreases the angiogenic potential of the ‘healthy’ urothelium adjacent to the tumor in patients with TCC. This observation could possibly explain, to a certain extent, the mechanism by which IFN-a2b reduces the recurrence rate of primary TCC.
© 2003 S. Karger GmbH, Freiburg
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