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Vol. 47, No. 3-4, 2003
Issue release date: May–August 2003
Section title: Review
Ann Nutr Metab 2003;47:107–113
(DOI:10.1159/000070031)

Food Contents and Biological Activity of 25-Hydroxyvitamin D: A Vitamin D Metabolite to Be Reckoned With?

Ovesen L. · Brot C. · Jakobsen J.
Institute of Food Safety and Nutrition, Danish Food Administration, Søborg, Denmark

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: 7/22/2002
Accepted: 9/24/2002
Published online: 5/16/2003

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

Only a limited number of foods naturally contain vitamin D such as fish, meat and offal, and eggs, and milk and dairy products. However, all these foods in addition contain the metabolite 25-hydroxyvitamin D (25OHD). From the few systematic studies which have been performed the food contents of 25OHD in animal foods are usually low but vary. Contents are typically very low in milk and fish (<0.1 µg/100 g), somewhat higher in meat and offal (0.2–0.4 µg/100 g) and up to 1 µg/100 g in egg yolk. It has been demonstrated that 25OHD is absorbed better and faster from the diet than native vitamin D and has metabolic effects of its own in regulating cell growth and calcium metabolism. Thus, the biological activity of 25OHD is greater than that of native vitamin D. However, there is as yet no consensus on the conversion factor that should be used for 25OHD to calculate vitamin D activity. Depending on the testing system used the factor varies from 1.5 to 5. If food contents and the higher potency of 25OHD are not included in dietary intake surveys, true vitamin D intake will be underestimated.


  

Author Contacts

Lars Ovesen, MD
Institute of Food Safety and Nutrition, Food Administration of Denmark
19 Mørkhøj Bygade
DK–2860 Søborg (Denmark)
Tel. +45 33 95 60 00, Fax +45 33 95 60 01, E-Mail lov@fdir.dk

  

Article Information

Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 0, Number of References : 78

  

Publication Details

Annals of Nutrition & Metabolism (European Journal of Nutrition, Metabolic Diseases and Dietetics)
Founded 1959 as ’Nutritio et Dieta‘ by E. Azerad, H. Kapp and J. Trémolières
Official Journal of the Federation of European Nutrition Societies (FENS)

Vol. 47, No. 3-4, Year 2003 (Cover Date: May-August 2003)

Journal Editor: I. Elmadfa, Vienna
ISSN: 0250–6807 (print), 1421–9697 (Online)

For additional information: http://www.karger.com/anm


Article / Publication Details

First-Page Preview
Abstract of Review

Received: 7/22/2002
Accepted: 9/24/2002
Published online: 5/16/2003

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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