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Vol. 64, No. 4, 2003
Issue release date: May 2003
Section title: Clinical Study
Oncology 2003;64:336–340
(DOI:10.1159/000070290)

18F-Fluorodeoxyglucose Positron Emission Tomography (18F-FDG-PET) for Staging and Follow-Up of Marginal Zone B-Cell Lymphoma

Hoffmann M.a · Kletter K.a · Becherer A.a · Jäger U.c · Chott A.b · Raderer M.c
Departments of aNuclear Medicine, bClinical Pathology and cInternal Medicine I, University of Vienna, Vienna, Austria

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Published online: 5/16/2003
Issue release date: May 2003

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Objective: According to recent reports, nodal marginal zone lymphoma (MZL) appears to be a distinctive lymphoma entity rather than a more advanced stage of extranodal MZL of mucosa-associated lymphoid tissue (MALT). We have therefore retrospectively evaluated all patients diagnosed with nodal or extranodal MZL who have been referred to our unit for imaging using 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET). Patients and Methods: A total of 21 patients with a diagnosis of MZL upon referral for imaging with 18F-FDG-PET were identified. Histological reassessment of biopsy specimens confirmed the diagnosis of extranodal MZL of MALT in 14 patients, while a diagnosis of nodal MZL was verified in 6 patients. Lymphoma cell proliferation was assessed immunohistochemically using a Ki-67 antibody. Whole-body 18F-FDG-PET scans were performed on a GE advanced PET scanner 40 min after intravenous injection of 300–380 MBq 18F-FDG. Results: None of the patients with extranodal MZL showed focal tracer uptake within verified tumor sites. In contrast, 5 of the 6 patients with nodal MZL showed significant FDG uptake within the affected lymph nodes. These results did not simply reflect the different growth fractions of the two lymphoma entities since the proliferation indices of the two groups did not differ significantly. Conclusion:18F-FDG-PET visualizes nodal MZL in a high proportion of patients whereas FDG uptake is undetectable in extranodal MZL. Although limited by the small number of patients, this study suggests that imaging with 18F-FDG-PET might play a potential role in the diagnostic workup of patients with nodal MZL involvement.


  

Author Contacts

Martha Hoffmann, MD
Department of Nuclear Medicine, University of Vienna
Währinger Gürtel 18–20
A–1090 Vienna (Austria)
Tel. +43 1 40 400 5551, Fax +43 1 40 400 5552, E-Mail martha.hoffmann@akh-wien.ac.at

  

Article Information

Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 1, Number of References : 20

  

Publication Details

Oncology (International Journal of Cancer Research and Treatment)
Founded 1948 as ‘Oncologia’ by H.R. Schinz; Continued by V. Richards (1967–1975), H. Wrba (1976–1992), P.P. Carbone (1993–2002)

Vol. 64, No. 4, Year 2003 (Cover Date: Released May 2003)

Journal Editor: D.L. Trump, Buffalo, N.Y.
ISSN: 0030–2414 (print), 1423–0232 (Online)

For additional information: http://www.karger.com/onc


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Published online: 5/16/2003
Issue release date: May 2003

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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