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Vol. 8, No. 4, 2003
Issue release date: July–August 2003
Section title: Original Paper
Audiol Neurootol 2003;8:207–221
(DOI:10.1159/000071061)

8-Iso-Prostaglandin F, a Product of Noise Exposure, Reduces Inner Ear Blood Flow

Miller J.M. · Brown J.N. · Schacht J.
Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Mich., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/22/2002
Accepted: 2/27/2003
Published online: 6/19/2003

Number of Print Pages: 15
Number of Figures: 11
Number of Tables: 0

ISSN: 1420-3030 (Print)
eISSN: 1421-9700 (Online)

For additional information: http://www.karger.com/AUD

Abstract

Noise exposure induces the formation in the cochlea of 8-isoprostaglandin F (8-iso-PGF), a marker for reactive oxygen species [Ohinata et al., 2000a] and a potent vasoconstrictor, raising the possibility that 8-iso-PGF may be responsible for noise-induced reductions in cochlear blood flow (CBF). To test this hypothesis, CBF was assessed in the guinea pig in response to ‘local’ (via the anterior inferior cerebellar artery) and systemic (i.v.) delivery of 8-iso-PGF using laser Doppler flowmetry. Local 8-iso-PGF induced a clear reduction in CBF. With systemic infusion, vascular conductance (VC), the ratio of CBF to systemic blood pressure, decreased in a dose-dependent manner up to 30%, consistent with an 8-iso-PGF-induced constriction of the cochlear vasculature. Infusion of SQ29548, a specific antagonist of 8-iso-PGF, appropriately blocked an 8-iso-PGF-induced CBF response. Similarly, noise-induced changes in CBF and VC were prevented by infusion of SQ29548 during noise exposure or by antioxidant treatment (glutathione monoethyl ester) prior to exposure. Prevention of isoprostane-mediated vasoconstriction may have clinical utility in the protection from noise-induced hearing loss.


  

Author Contacts

Josef M. Miller, PhD
Kresge Hearing Research Institute, University of Michigan
1301 East Ann Street
Ann Arbor, MI 48109-0506 (USA)
Tel. +1 734 763 5098, Fax +1 734 764 0014, E-Mail josef@umich.edu

  

Article Information

Received: October 22, 2002
Accepted after revision: February 27, 2003
Number of Print Pages : 15
Number of Figures : 11, Number of Tables : 0, Number of References : 49

  

Publication Details

Audiology & Neuro-Otology (Basic Research and Clinical Applications)

Vol. 8, No. 4, Year 2003 (Cover Date: July-August 2003)

Journal Editor: Manfried Hoke, Münster, Germany
ISSN: 1420–3030 (print), 1421–9700 (Online)

For additional information: http://www.karger.com/aud


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/22/2002
Accepted: 2/27/2003
Published online: 6/19/2003

Number of Print Pages: 15
Number of Figures: 11
Number of Tables: 0

ISSN: 1420-3030 (Print)
eISSN: 1421-9700 (Online)

For additional information: http://www.karger.com/AUD


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