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Table of Contents
Vol. 10, No. 4, 2003
Issue release date: July – August
Section title: Review
J Biomed Sci 2003;10:361–366
(DOI:10.1159/000071155)

A Light in Multidrug Resistance: Photodynamic Treatment of Multidrug-Resistant Tumors

Capella M.A.M.a,b · Capella L.S.c
aInstituto de Biofísica Carlos Chagas Filho, bDepartamento de Bioquímica Médica, Universidade Federal do Rio de Janeiro, cDepartamento de Clínica Médica, Universidade do Rio de Janeiro, Rio de Janeiro, Brasil

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: March 21, 2003
Accepted: March 24, 2003
Published online: June 27, 2003
Issue release date: July – August

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 0

ISSN: 1021-7770 (Print)
eISSN: 1423-0127 (Online)

For additional information: http://www.karger.com/JBS

Abstract

The major drawback of cancer chemotherapy is the development of multidrug-resistant (MDR) tumor cells, which are cross-resistant to a broad range of structurally and functionally unrelated agents, making it difficult to treat these tumors. In the last decade, a number of authors have studied the effects of photodynamic therapy (PDT), a combination of visible light with photosensitizing agents, on MDR cells. The results, although still inconclusive, have raised the possibility of treating MDR tumors by PDT. This review examines the growing literature concerning the responses of MDR cells to PDT, while stressing the need for the development of new photosensitizers that possess the necessary characteristics for the photodynamic treatment of this class of tumor.

© 2003 National Science Council, ROC and S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Review

Received: March 21, 2003
Accepted: March 24, 2003
Published online: June 27, 2003
Issue release date: July – August

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 0

ISSN: 1021-7770 (Print)
eISSN: 1423-0127 (Online)

For additional information: http://www.karger.com/JBS


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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