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Clinical Study

Impact of Overall Treatment Time on Local Control of Anal Cancer Treated with Radiochemotherapy

Graf R.a · Wust P.a · Hildebrandt B.b · Gögler H.c · Ullrich R.a · Herrmann R.d · Riess H.b · Felix R.a

Author affiliations

aCenter of Radiation Medicine and bMedical Clinic for Hematology and Oncology, Campus Virchow Clinic, Charité Medical School, Humboldt University, and cSurgical Department, DRK Hospital, Westend Clinics, Berlin, Germany; dDepartment of Oncology, University Hospital Basel, Basel, Switzerland

Related Articles for ""

Oncology 2003;65:14–22

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: October 29, 2002
Published online: July 04, 2003
Issue release date: July 2003

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 5

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Between 1987 and 2000, 111 patients with epidermoid anal cancer (T1–T4 Nx M0) were assigned to primary simultaneous radiochemotherapy (RCT) with a radiation dose of 45 Gy, performed either as a split course with 2-Gy single fractions (schedule A, 1987–1996, n = 65 patients) or continuously with fractions of 1.8 Gy (schedule B, 1996–2000; n = 38 patients). The chemotherapy consisted of continuous infusions of 5-fluorouracil (5-FU; 800/1,000 mg/m2/day, on 4/5 consecutive days, during weeks 1 and 5) together with one (schedule A) or two (schedule B) short infusions of mitomycin C (10 mg/m2) during the first course of 5-FU. Associations between clinical outcome and various prognostic factors were assessed in 103 patients who completed these schedules. For both patient groups combined, 5-year local control rate was 67% and 5-year survival rate 71%. Advanced tumor stage, size, and nodal status significantly decreased the 5-year local control rate as well as the overall treatment time (OTT) >41 days (58% for OTT >41 days vs. 79% for OTT ≤41 days; p = 0.04). However, we did not find a correlation with the prescribed radiotherapy schedule (A or B). In conclusion, in patients with anal carcinomas treated with RCT with a radiation dose of 45 Gy, the predominant determinant of local control is the resulting OTT and not the administration schedule (split course or continuous radiotherapy).

© 2003 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: October 29, 2002
Published online: July 04, 2003
Issue release date: July 2003

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 5

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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