Case-Control Family Study of Lesser Variant Traits in AutismWilcox J.A. · Tsuang M.T. · Schnurr T. · Baida-Fragoso N.
aDepartment of Psychiatry, Texas Tech University Health Sciences Center, El Paso, Tex., and bHarvard Medical School, Boston, Mass., USA
Family data were obtained from the relatives of 30 autistic patients, 30 patients with other pervasive developmental disorder and 30 healthy controls. Detailed interviewing was conducted to document any evidence of psychiatric illness of the family members of these probands. Anxiety disorders and obsessive-compulsive illness stood out as being closely associated with having autistic individuals in the family. The findings suggest that autism is a spectrum disorder that may be associated with anxiety and obsessive-compulsive illness. This type of association is consistent with a polygenic threshold effect for this group of conditions.
James A. Wilcox, DO, PhD
Texas Tech University Health Sciences Center
Department of Psychiatry, 4800 Alberta Avenue
El Paso, TX 79905 (USA)
Tel. +1 915 545 6831, Fax +1 915 545 6442, E-Mail firstname.lastname@example.org
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 3, Number of References : 83
Founded 1975 by J. Mendlewicz (Brussels)
Official Journal of the International Pharmaco-EEG Society (IPEG)
Vol. 47, No. 4, Year 2003 (Cover Date: Released June 2003)
Journal Editor: P. Netter, Giessen; J. Mendlewicz, Brussels; B. Saletu, Vienna
ISSN: 0302–282X (print), 1423–0224 (Online)
For additional information: http://www.karger.com/nps