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Vol. 70, No. 6, 2002/2003
Issue release date: July 2003
Section title: Original Paper
Pathobiology 2002–03;70:361–367
(DOI:10.1159/000071277)

Resistance of Epiphyseal Cartilage to Invasion by Osteosarcoma Is Likely to Be Due to Expression of Antiangiogenic Factors

Quan G.M.Y. · Ojaimi J. · Nadesapillai A.P.W. · Zhou H. · Choong P.F.M.
Departments of aOrthopaedics and bMedicine, University of Melbourne, St. Vincent’s Hospital Melbourne, and cDivision of Surgical Oncology, Peter MacCallum Cancer Institute, Melbourne, Vic., Australia

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/8/2002
Accepted: 3/7/2003
Published online: 7/17/2003

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 0

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: http://www.karger.com/PAT

Abstract

Objectives: Epiphyseal cartilage is a barrier to osteosarcoma invasion, however the mechanisms behind this resistance remain unclear. The aim of this study was to examine the chronological and spatial patterns of osteosarcoma growth and invasion of local tissue structures including epiphyseal cartilage. Methods: We used an in vivomouse model of osteosarcoma to histologically examine tumors at different stages of disease progression. We compared the pattern of osteosarcoma penetration of epiphyseal cartilage with the expression pattern of two potent mediators of angiogenesis; proangiogenic vascular endothelial growth factor (VEGF) and antiangiogenic pigment epithelium-derived factor (PEDF). Results: Epiphyseal cartilage remained intact across its entire length in all sections examined, despite increasing tumor size as well as intra- and extraosseous destruction. In the most advanced cases, only the proangiogenic lowermost layers of the hypertrophic zone of the growth plate were eroded. This corresponded with the growth plate layers which highly expressed the angiogenic factor VEGF. In contrast, the resting, proliferative and upper hypertrophic layers were resistant to osteosarcoma invasion in all cases. This corresponded to the layers with the highest expression of the potent antiangiogenic factor PEDF. Conclusion: Epiphyseal cartilage is resistant to local invasion by osteosarcoma. The balance of angiogenesis, influenced by pro- and antiangiogenic factors, is likely to play an important role in this resistance.


  

Author Contacts

Professor Peter F.M. Choong
Department of Orthopaedics
St. Vincent’s Hospital Melbourne, PO Box 2900
Fitzroy, Vic. 3065 (Australia)
Tel. +61 3 9288 3960, Fax +61 3 9416 3610, E-Mail sarcomasurgeon@ozemail.com.au

  

Article Information

Received: October 8, 2002
Accepted after revision: March 7, 2003
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 0, Number of References : 30

  

Publication Details

Pathobiology
Founded 1938 as ‘Schweizerische Zeitschrift für allgemeine Pathologie und Bakteriologie’ by A. v. Albertini, A. Grumbach and H. Mooser

Vol. 70, No. 6, Year 2002/2003 (Cover Date: Released July 2003)

Journal Editor: Ch. Wittekind, Leipzig
ISSN: 1015–2008 (print), 1423–0291 (Online)

For additional information:http://www.karger.com/pat


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/8/2002
Accepted: 3/7/2003
Published online: 7/17/2003

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 0

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: http://www.karger.com/PAT


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