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Association between Serum Carcinoembryonic Antigen and Endothelial Cell Adhesion Molecules in Colorectal CancerRoselli M.a · Guadagni F.b · Martini F.c · Spila A.b · Mariotti S.a · D’Alessandro R.b · Aloe S.b · Gazzaniga P.P.c · Basili S.d · Cosimelli M.e · Ferroni P.c
aDepartment of Surgery, Medical Oncology, University of Rome ‘Tor Vergata’, bLaboratory of Clinical Pathology, Regina Elena Cancer Institute, Departments of cExperimental Medicine and Pathology and dMedical Therapy, Policlinico Umberto I, University of Rome ‘La Sapienza’, and eDepartment of Surgery, Regina Elena Cancer Institute, Rome, Italy
Objectives: To analyse the behaviour of pre-surgical serum levels of soluble (s)E-selectin and vascular cell adhesion molecule (sVCAM) in patients with colorectal cancer, and to evaluate their possible correlation with carcinoembryonic antigen (CEA), pro-inflammatory cytokines and clinicopathological features with respect to their prognostic value in predicting metastatic disease. Methods: Pre-surgical serum levels of sE-selectin, sVCAM, interleukin-6 (IL-6), IL-1β, tumour necrosis factor-α (TNF-α) and CEA were measured in 194 patients with colorectal adenocarcinoma, 40 patients with benign colorectal diseases and 59 healthy subjects. Results: sE-selectin, sVCAM, TNF-α and IL-6 levels were significantly higher in patients with colorectal cancer compared to either healthy subjects or patients with benign disease. Positive rates of sE-selectin, sVCAM and TNF-α levels were significantly associated with Dukes’ stage D colorectal cancer, and all three variables were independently associated to the presence of distant metastases. Positive sE-selectin, sVCAM and TNF-α levels were significantly associated to CEA. TNF-α and CEA levels were independently related to the presence of positive levels of sE-selectin and/or sVCAM. Conclusions: Our findings suggest that the host inflammatory response to cancer cells, and/or their released products (i.e. CEA), might be responsible (via cytokine release) for the elevation in circulating adhesion molecules in patients with colorectal cancer.
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