Myelosuppression represents a major side effect of cytotoxic anti-cancer agents. Infection due to granulocytopenia and the risk of bleeding due to thrombocytopenia compromise the potential of curative and palliative chemotherapy. Considering the many chemotherapeutic agents for which drug resistance genes have been described, and the recent improvements in vector and transduction technology, it seems conceivable that drug resistance gene transfer into a patient’s autologous hematopoietic stem or progenitor cells will be able to reduce or abolish chemotherapy-induced myelosuppression.
Priv.-Doz. Dr. Michael Flasshove
Department of Internal Medicine (Cancer Research)
West German Cancer Center, University of Essen Medical School
Hufelandstrasse 55, DE–45122 Essen (Germany)
Tel. +49 201 723 3116, Fax +49 201 723 2178, E-Mail firstname.lastname@example.org
Number of Print Pages : 14
Number of Figures : 2, Number of Tables : 1, Number of References : 145
Affiliated with the ‘Molecular Biology of Hematopoiesis’ Symposia
Vol. 110, No. 2-3, Year 2003 (Cover Date: Released October 2003)
Journal Editor: I. Ben-Bassat, Tel Hashomer
ISSN: 0001–5792 (print), 1421–9662 (Online)
For additional information: http://www.karger.com/aha
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