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Vol. 16, No. 4, 2003
Issue release date: September 2003
Section title: Original Paper
Cerebrovasc Dis 2003;16:389–395
(DOI:10.1159/000072562)

Design and Baseline Characteristics of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/4/2003
Accepted: 2/14/2003
Published online: 9/19/2003
Issue release date: September 2003

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Evidence suggests that statin therapy reduces the risk of stroke in patients with coronary heart disease (CHD), but its benefit for patients with cerebrovascular disease and no history of CHD remains uncertain. The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study is a prospective, multi-centre, double-blind, randomised, placebo-controlled trial designed to evaluate the effects of atorvastatin 80 mg/day in patients who previously experienced a stroke or transient ischaemic attack, but who have no known CHD. A total of 4,732 patients have been enrolled, and the data collection phase of the study is expected to be completed by October 2004. SPARCL is the first study primarily designed to prospectively evaluate the effect of statin treatment in secondary stroke prevention.

© 2003 S. Karger AG, Basel


  

Author Contacts

Henrik Sillesen, MD, DMSc
Department of Vascular Surgery
Gentofte University Hospital
DK–2900 Hellerup (Denmark)
Tel. +45 3977 3402, Fax +45 3977 7674, E-Mail hens@gentoftehosp.kbhamt.dk

  

Article Information

Received: February 4, 2003
Accepted: February 14, 2003
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 3, Number of References : 31

  

Publication Details

Cerebrovascular Diseases (Official Journal of the European Stroke Council)

Vol. 16, No. 4, Year 2003 (Cover Date: Released September 2003)

Journal Editor: J. Bogousslavsky, Lausanne; M.G. Hennerici, Mannheim
ISSN: 1015–9770 (print), 1421–9786 (Online)

For additional information: http://www.karger.com/journals/ced


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/4/2003
Accepted: 2/14/2003
Published online: 9/19/2003
Issue release date: September 2003

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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