Evidence suggests that statin therapy reduces the risk of stroke in patients with coronary heart disease (CHD), but its benefit for patients with cerebrovascular disease and no history of CHD remains uncertain. The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study is a prospective, multi-centre, double-blind, randomised, placebo-controlled trial designed to evaluate the effects of atorvastatin 80 mg/day in patients who previously experienced a stroke or transient ischaemic attack, but who have no known CHD. A total of 4,732 patients have been enrolled, and the data collection phase of the study is expected to be completed by October 2004. SPARCL is the first study primarily designed to prospectively evaluate the effect of statin treatment in secondary stroke prevention.
© 2003 S. Karger AG, Basel
Henrik Sillesen, MD, DMSc
Department of Vascular Surgery
Gentofte University Hospital
DK–2900 Hellerup (Denmark)
Tel. +45 3977 3402, Fax +45 3977 7674, E-Mail firstname.lastname@example.org
Received: February 4, 2003
Accepted: February 14, 2003
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 3, Number of References : 31
Cerebrovascular Diseases (Official Journal of the European Stroke Council)
Vol. 16, No. 4, Year 2003 (Cover Date: Released September 2003)
Journal Editor: J. Bogousslavsky, Lausanne; M.G. Hennerici, Mannheim
ISSN: 1015–9770 (print), 1421–9786 (Online)
For additional information: http://www.karger.com/journals/ced
Article / Publication Details
Published online: 9/19/2003
Issue release date: September 2003
Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3
ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)
For additional information: http://www.karger.com/CED
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