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Table of Contents
Vol. 71, No. 1, 2004
Issue release date: October 2003
Section title: Original Paper
Pathobiology 2004;71:12–18
(DOI:10.1159/000072957)

Expression of Uridine Diphosphate N-Acetyl-α-D-Galactosamine: Polypeptide N-Acetylgalactosaminyl Transferase 3 in Adenocarcinoma of the Pancreas

Yamamoto S.a · Nakamori S.a · Tsujie M.a · Takahashi Y.a · Nagano H.a · Dono K.a · Umeshita K.a · Sakon M.a · Tomita Y.b · Hoshida Y.b · Aozasa K.b · Kohno K.c · Monden M.a
Departments of aSurgery and Clinical Oncology and bPathology, Osaka University Graduate School of Medicine, and cDepartment of Molecular Biology, University of Occupational and Environmental Health, Osaka School of Medicine, Fukuoka, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 07, 2003
Accepted: March 07, 2003
Published online: October 16, 2003
Issue release date: October 2003

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: http://www.karger.com/PAT

Abstract

Uridine diphosphate (UDP) N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyl transferase 3 (GalNAc-T3), one of the enzymes that catalyze the initial glycosylation of mucin type O-linked proteins, was shown to associate with the differentiation of cancer cell lines and the prognosis of some kinds of cancers. In the present study, the association of GalNAc-T3 expression with clinicopathologic features of pancreatic adenocarcinoma and patients’ survival was examined. The level of expression of GalNAc-T3 was analyzed immunohistochemically in paraffin-embedded tumor samples from surgically resected specimens of 59 patients with pancreatic ductal adenocarcinoma. The correlations of GalNAc-T3 expression with clinicopathologic features and prognosis were studied. Thirty-five tumors showed high- intensity GalNAc-T3 staining, whereas 24 showed low-intensity staining. A close association was observed between GalNAc-T3 staining intensity and histologic differentiation and the stage of the tumors. The low-intensity group showed a high rate of the poorly differentiated subtype (p < 0.001) and T4 of the pTNM staging system (p < 0.05). These findings indicate that the expression of GalNAc-T3 is associated with the differentiation and aggressiveness of ductal adenocarcinoma of the pancreas.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 07, 2003
Accepted: March 07, 2003
Published online: October 16, 2003
Issue release date: October 2003

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: http://www.karger.com/PAT


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