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Table of Contents
Vol. 46, No. 5, 2000
Issue release date: September–October 2000
Section title: Microbiology
Chemotherapy 2000;46:309–314
(DOI:10.1159/000007303)

Comparative in vitro Activity of Older and Newer Fluoroquinolones against Respiratory Tract Pathogens

Esposito S. · Noviello S. · Ianniello F.
Clinica Malattie Infettive, Seconda Università dagli Studi di Napoli, Italia

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Article / Publication Details

First-Page Preview
Abstract of Microbiology

Published online: 8/17/2000
Issue release date: September–October 2000

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE

Abstract

The aim of this study was to evaluate the antibacterial activity of older (ciprofloxacin and ofloxacin) and newer (moxifloxacin, grepafloxacin, sparfloxacin and levofloxacin) fluoroquinolones. Minimal inhibitory concentrations (MICs) were determined, according to the NCCLS guidelines, against the following respiratory tract pathogens: penicillin-susceptible and -resistant Streptococcus pneumoniae, β-lactamase-positive and βlactamase-negative Haemophilus influenzae and β-lactamase-positive Moraxella catarrhalis. In addition, we evaluated the minimal bactericidal concentrations of the same antibiotics against all the pneumococci and the haemophili. Finally, the activity of ciprofloxacin, ofloxacin, sparfloxacin and moxifloxacin against 15 pneumococci were investigated by time-kill analysis. All fluoroquinolones tested exhibited a similar, good activity against H. influenzae and M. catarrhalis. Against S. pneumoniae, irrespective of penicillin susceptibility, moxifloxacin, grepafloxacin, sparfloxacin and levofloxacin exhibited excellent activity, better than ciprofloxacin and ofloxacin. Time-kill analysis showed that 99.9% killing of all strains was obtained after 24 h with moxifloxacin at 2 × MIC, whereas other antimicrobials obtained similar results at 4 × MIC. Moxifloxacin is characterized by an improved activity against respiratory pathogens, including penicillin-resistant and -susceptible S. pneumoniae. Its activity is not influenced by β-lactamase production. These results suggest that moxifloxacin represents a promising alternative for treatment of respiratory tract infections.

© 2000 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Microbiology

Published online: 8/17/2000
Issue release date: September–October 2000

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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