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Vol. 60, No. 4, 2003
Issue release date: 2003
Section title: Original Paper
Horm Res 2003;60:174–180
(DOI:10.1159/000073229)

Pilot Study of Elevated Levels of Insulin-Like Growth Factor-Binding Protein-2 as Indicators of Hepatocellular Carcinoma

Ranke M.B.a · Maier K.-P.b · Schweizer R.a · Stadler B.b · Schleicher S.c · Elmlinger M.a · Flehmig B.c
aPaediatric Endocrinology Section, University Children’s Hospital, Tübingen, bDepartment of Gastroenterology, Städtische Kliniken, Esslingen, and cDepartment of Virology, University Children’s Hospital, Tübingen, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/13/2002
Accepted: 6/6/2003
Published online: 10/15/2003
Issue release date: 2003

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Background/Aims: Insulin-like growth factor-binding protein-2 (IGFBP-2) is expressed in many malignant tissues, and elevated serum levels can be indicators of tumour activity in addition to conventional tumour markers. Our aim was to evaluate the role of IGFBP-2 levels together with insulin-like growth factor (IGF)-I, IGF-II and IGFBP-3 in the diagnostic work-up of patients with hepatocellular carcinoma (HCC). Methods: In 50 (39 males, 11 females) histologically confirmed and TNM-graded patients with HCC who had not received adjuvant chemotherapy, the basal serum levels of IGF-I, IGF-II, IGFBP-3, IGFBP-2 and α-fetoprotein (AFP) were measured. The median age of the patients was 66 (37–84) years, body mass index was normal (25 (35–16) kg/m2). Results: The levels of IGF-I, IGF-II and IGFBP-3 were diminished, as is the case when nutrition, hepatic function and growth hormone (GH) secretion are decreased. The levels of AFP and IGFBP-2 were markedly high. In 37 cases, IGFBP-2 levels were above the age-related norm, and in 40 cases AFP levels were also elevated. In 3 cases, both AFP and IGFBP-3 were normal, and in 4 cases AFP was high but IGFBP-2 normal, whereas in 10 cases AFP was normal but IGFBP-2 was high. Conclusions: In addition to AFP, IGFBP-2 appears to be a suitable marker for the evaluation of the serological status of HCC patients. A longitudinal study during disease management is required to assess the full potential of IGFBP-2 measurements as a marker.

© 2003 S. Karger AG, Basel


  

Author Contacts

Prof. Michael B. Ranke
Paediatric Endocrinology Section
University Children’s Hospital
Hoppe-Seyler-Strasse 1, DE–72076 Tübingen (Germany)
Tel. +49 7071 298 3417, Fax +49 7071 29 4157, E-Mail mlranke@med.uni-tuebingen.de

  

Article Information

Received: September 13, 2002
Accepted: June 6, 2003
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 2, Number of References : 48

  

Publication Details

Hormone Research (International Journal of Experimental and Clinical Endocrinology)
Founded 1970 as ‘Hormones’ by M. Marois, Continued 1976 by J. Girard (1976–1995)
Official Organ of the European Society for Paediatric Endocrinology

Vol. 60, No. 4, Year 2003 (Cover Date: 2003)

Journal Editor: M.B. Ranke, Tübingen
ISSN: 0301–0163 (print), 1423–0046 (Online)

For additional information: http://www.karger.com/journals/hre


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/13/2002
Accepted: 6/6/2003
Published online: 10/15/2003
Issue release date: 2003

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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