Changes in the intensity of repeated, ignored sounds elicit the mismatch negativity (MMN) brain response which reflects preattentive detection of the change. It is generally assumed that the MMN in response to intensity changes reflects a memory-based comparison mechanism rather than being due to differential states of refractoriness of intensity-specific cortical neurons. In the present study, an experimental protocol consisting of 4 oddball blocks and 1 control block was used in order to separate memory-comparison-related effects from refractoriness-related ones. This design allowed an assessment of intensity MMN using physically identical stimuli with equal probability of occurrence in separate blocks, while avoiding contamination by refractoriness. Results were consistent with an MMN in response to intensity change that reflects genuine memory-based comparison.
© 2003 S. Karger AG, Basel
Received: April 8, 2003
Accepted after revision: June 16, 2003
Number of Print Pages : 9
Number of Figures : 5, Number of Tables : 0, Number of References : 27
Audiology & Neuro-Otology (Basic Research and Clinical Applications)
Vol. 8, No. 6, Year 2003 (Cover Date: November-December 2003)
Journal Editor: Manfried Hoke, Münster, Germany
ISSN: 1420–3030 (print), 1421–9700 (Online)
For additional information: http://www.karger.com/aud
Article / Publication Details
Published online: 10/24/2003
Issue release date: November–December 2003
Number of Print Pages: 9
Number of Figures: 5
Number of Tables: 0
ISSN: 1420-3030 (Print)
eISSN: 1421-9700 (Online)
For additional information: http://www.karger.com/AUD
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