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Vol. 70, No. 5, 2003
Issue release date: September–October 2003
Section title: Clinical Investigations
Respiration 2003;70:490–495
(DOI:10.1159/000074205)

Abnormalities of the Respiratory Function and Control of Ventilation in Patients with Anorexia nervosa

González-Moro J.M.R. · de Miguel-Díez J. · Paz-González L. · Buendía-García M.J. · Santacruz-Siminiani A. · de Lucas-Ramos P.
Departments of Pneumology,aHospital General Universitario Gregorio Marañón, Madrid, bHospital Morales Meseguer, Murcia, and cHospital Santa María del Rosell, Murcia, Spain

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Article / Publication Details

First-Page Preview
Abstract of Clinical Investigations

Received: 8/29/2002
Accepted: 3/24/2003
Published online: 12/5/2003

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 5

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES

Abstract

Background: Anorexia nervosa is a good model to study the effects of malnutrition on the respiratory system, since it excludes the consequences that some chronic diseases can have on the lung. Objective: The objective of this study was to assess pulmonary function and alterations in the respiratory system in patients with anorexia nervosa. Methods: Twenty-two women, 12 with anorexia nervosa and 10 healthy volunteers, were studied. Anthropometric data were gathered for all the participants. In every case, an arterial blood gas test and functional respiratory study, that included spirometry, plethysmography, measure of maximum muscular respiratory pressure and study of the ventilatory pattern at baseline and after hypercapnic stimulation, were performed. Results: No significant differences were found in mean age and height in both groups of patients but there was a difference in body mass index (p < 0.05). In pulmonary function tests, an increase in residual volume (RV), RV/total lung capacity (TLC) ratio and functional residual capacity and a decrease in maximum respiratory pressure were found in patients with anorexia nervosa compared to the control group (p < 0.05). Differences were also found in the ventilatory pattern, with a reduction in minute ventilation and occlusion pressure as well as a decreased response of these parameters to hypercapnic stimulation (p < 0.05) in the patients with anorexia nervosa. Conclusion: In patients with anorexia nervosa, a significant elevation in RV, in the RV/TLC ratio and in functional residual capacity and a decrease in the maximum respiratory pressure were noted. In addition, they present an alteration in the central respiratory drive and a response of the respiratory system to hypercapnic stimulation. Although these alterations have no repercussion on the maintenance of gas exchange in baseline conditions, they may have in extreme situations.


  

Author Contacts

J.M.R. González-Moro
Servicio de Neumología
Hospital General Universitario Gregorio Marañón
C/ Doctor Esquerdo, 46, ES–28007 Madrid (Spain)
Tel. +34 91 5868330, Fax +34 91 5868018, E-Mail jrg04m@saludalia.com

  

Article Information

Received: August 29, 2002
Accepted after revision: April 24, 2003
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 5, Number of References : 24

  

Publication Details

Respiration (International Review of Thoracic Diseases)
Founded 1944 as ‘Schweizerische Zeitschrift für Tuberkulose und Pneumonologie’ by E. Bachmann, M. Gilbert, F. Häberlin, W. Löffler, P. Steiner and E. Uehlinger, continued 1962–1967 as ‘Medicina Thoracalis’ as of 1968 as ‘Respiration’, H. Herzog (1962–1997)
Official Journal of the European Association for Bronchology and Interventional Pulmonology

Vol. 70, No. 5, Year 2003 (Cover Date: September-October 2003)

Journal Editor: C.T. Bolliger, Cape Town
ISSN: 0025–7931 (print), 1423–0356 (Online)

For additional information: http://www.karger.com/journals/res


Article / Publication Details

First-Page Preview
Abstract of Clinical Investigations

Received: 8/29/2002
Accepted: 3/24/2003
Published online: 12/5/2003

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 5

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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