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Table of Contents
Vol. 101, No. 3-4, 2003
Issue release date: 2003
Section title: Paper
Cytogenet Genome Res 101:199–205 (2003)
(DOI:10.1159/000074337)

Expression studies of the PIS-regulated genes suggest different mechanisms of sex determination within mammals

Pannetier M.a · Servel N.a · Cocquet J.c · Besnard N.b · Cotinot C.a · Pailhoux E.a
aBiologie du Développement et Reproduction et bGénétique Biochimique et Cytogénétique – INRA Bât J. Poly; Jouy-en-Josas; cInserm U361, Institut Cochin, Paris (France)

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: May 27, 2003
Accepted: June 18, 2003
Published online: December 17, 2003
Issue release date: 2003

Number of Print Pages: 7
Number of Figures: 6
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

In mammals, the Y-located SRY gene is known to induce testis formation from the indifferent gonad. A related gene, SOX9, also plays a critical role in testis differentiation in mammals, in birds and reptiles. It is now assumed that SRY acts upstream of SOX9 in the sex determination cascade, but the regulatory link which should exist between these two genes remains unknown. Studies on XX sex reversal in polled goats (PIS mutation: Polled Intersex Syndrome) have led to the discovery of a female-specific locus crucial for ovarian differentiation. This genomic region is composed of at least two genes, FOXL2 and PISRT1, which share a common transcriptional regulatory region, PIS. In this review, we present the expression pattern of these PIS-regulated genes in mice. The FOXL2 expression profile of mice is similar to that described in goats in accordance with a conserved role of this ovarian differentiating gene in mammals. On the contrary, the PISRT1 expression profile is different between mice and goats, suggesting different mechanisms of the primary switch in the testis determination process within mammals. A model based on two different modes of SOX9 regulation in mice and other mammals is proposed in order to integrate our results into the current scheme of gonad differentiation.   

© 2003 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: May 27, 2003
Accepted: June 18, 2003
Published online: December 17, 2003
Issue release date: 2003

Number of Print Pages: 7
Number of Figures: 6
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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