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Vol. 101, No. 3-4, 2003
Issue release date: 2003
Section title: Paper
Cytogenet Genome Res 101:261–265 (2003)
(DOI:10.1159/000074346)

Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours

Bowles J. · Teasdale R.P. · James K. · Koopman P.
aInstitute for Molecular Bioscience; bAustralian Research Council Centre of Excellence in Biotechnology and Development, The University of Queensland, Brisbane, Queensland (Australia)

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 6/27/2003
Accepted: 9/15/2003
Published online: 12/17/2003

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

We identified a transcript named 11M2 on the basis of its strong male-specific expression pattern in the developing mouse gonad. 11M2 was found to be expressed by gonad primordial germ cells (PGCs) of both sexes and down-regulated in female PGCs as they enter prophase I of the first meiotic division, similar to the expression of Oct4. Mouse EST analysis revealed expression only in early-stage embryos, embryonic stem cells and pre-meiotic germ cells. 11M2 corresponds to a recently reported gene variously known as PGC7, stella or Dppa3. We have identified the human orthologue of Dppa3 and find by human EST analysis that it is expressed in human testicular germ cell tumours but not in normal human somatic tissues. The expression patterns of mouse and human DPPA3, in undifferentiated embryonic cells, embryonic germ cells and adult germ cell tumours, together suggest a role for this gene in maintaining cell pluripotentiality.    


  

Author Contacts

Request reprints from Peter Koopman, Institute for Molecular Bioscience
The University of Queensland, Brisbane 4072, Queensland (Australia)
telephone: 61 7 3346 2061; fax: 61 7 3346 2101;e-mail: p.koopman@imb.uq.edu.au

  

Article Information

Supported by the National Health and Medical Research Council of Australia. P.K. is a Professorial Research Fellow of the Australian Research Council.

Received 27 June 2003;
manuscript accepted 15 September 2003.
Number of Print Pages : 5
Number of Figures : 3, Number of Tables : 0, Number of References : 18

  

Publication Details

Cytogenetic and Genome Research
Formerly ‘Cytogenetics and Cell Genetics’

Vol. 101, No. 3-4, Year 2003 (Cover Date: 2003)

Journal Editor: H.P. Klinger, Bronx, N.Y.; M. Schmid, Würzburg
ISSN: 1424–8581 (print), 1424–859X (Online)

For additional information: http://www.karger.com/journals/cgr


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 6/27/2003
Accepted: 9/15/2003
Published online: 12/17/2003

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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