MMSE Cross-Domain Variability Predicts Cognitive Decline in CentenariansKliegel M. · Sliwinski M.
aInstitute of Psychology, Department of Gerontopsychology, University of Zurich, Zurich, Switzerland; bDepartment of Psychology, Syracuse University, Syracuse, N.Y., USA
Background: Early detection of dementia is one of the key issues in cognitive gerontology. However, so far the detection of early stages in cognitive decline has been rather unreliable. One central limitation of current assessment strategies is that they rely on information about a person’s level of performance obtained from a single assessment. Objective: In the first part of the present paper, we propose three strategies for overcoming this limitation by using information from several measurement occasions to improve diagnostic reliability. Methods: In the second part, we present one exemplary empirical analysis of one of these approaches reporting data from the Heidelberg Centenarian Study. Results: In this sample of very old individuals tested at baseline and at a follow-up 18 months later, the intra-individual cross-domain variability across MMSE subscales at baseline predicted cognitive decline (i.e. change in an external cognitive functioning rating from baseline to follow-up) much better than baseline mean MMSE scores. Conclusions: In conclusion, we discuss the advantage of performance varibility as a predictor for cognitive decline.
Institute of Psychology, Department of Gerontopsychology
University of Zurich, Schaffhauserstrasse 15
CH–8006 Zürich (Switzerland)
Tel. +41 1 635 3431, Fax +41 1 635 3421, E-Mail firstname.lastname@example.org
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 1, Number of References : 20
Gerontology (International Journal of Experimental, Clinical and Behavioural Gerontoloy)
Founded 1957 by F. Verzàr as ‘Gerontologia’, merged 1975 with ‘Gerontologia Clinica’, founded 1959 by E. Woodford-Williams and A.N. Exton-Smith
Organ of the International Association of Gerontology (IAG)
Vol. 50, No. 1, Year 2004 (Cover Date: January-February 2004)
Journal Editor: W. Meier-Ruge, Basel
ISSN: 0304–324X (print), 1423–0003 (Online)
For additional information: http://www.karger.com/journals/ger