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Table of Contents
Vol. 24, No. 4, 2003
Issue release date: December 2003
Section title: Research Article
Tumor Biol 2003;24:209–218
(DOI:10.1159/000074432)

Tumor Markers (CEA, CA 125, CYFRA 21-1, SCC and NSE) in Patients with Non-Small Cell Lung Cancer as an Aid in Histological Diagnosis and Prognosis

Comparison with the Main Clinical and Pathological Prognostic Factors

Molina R.a · Filella X.a · Augé J.M.a · Fuentes R.c · Bover I.d · Rifa J.e · Moreno V.b · Canals E.c · Viñolas N.a · Marquez A.e · Barreiro E.c · Borras J.d · Viladiu P.c
aLaboratory of Clinical Biochemistry, Unit for Cancer Research, Hospital Clínic, and bUnit of Epidemiology and Cancer Registry, Hospital Duran i Reynals, Barcelona, and Departments of Oncology, cHospital Santa Caterina, Girona, dHospital San Joan de Reus, Tarragona, and eHospital Son Dureta, Palma de Mallorca, Spain

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Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: February 10, 2003
Accepted: September 11, 2003
Published online: December 08, 2003
Issue release date: December 2003

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 6

ISSN: 1010-4283 (Print)
eISSN: 1423-0380 (Online)

For additional information: http://www.karger.com/TBI

Abstract

CEA, CA 125, SCC, CYFRA 21-1 and NSE were prospectively studied in 211 patients with non-small cell lung cancer and compared with clinical parameters (age, sex, Karnofsky Index, symptoms and smoking status), histopathological parameters (stage, histology, tumor size and nodal involvement), biological parameters (LDH and albumin) and the therapy used (surgery, chemotherapy or radiotherapy). Tumor marker sensitivity was CYFRA 21-1: 76%, CA 125: 55%, CEA: 52%, SCC: 33% and NSE: 22%. One of the tumor markers was abnormally high in 87% of the patients with locoregional disease and in 100% of the patients with metastases. Except for NSE, all tumor markers showed a clear relationship with tumor stage and histology and therefore enabled a better histological diagnosis. Abnormal CEA serum levels were mainly found in adenocarcinomas, CA 125 in large-cell lung cancers (LCLC) and adenocarcinomas and SCC in squamous tumors. Eighty-five percent of the patients with SCC levels >2 ng/ml had squamous tumors. Likewise, CA 125 levels <60 U/ml or CEA <10 ng/ml excluded adenocarcinoma or LCLC with a probability of 82 and 91%, respectively.

© 2003 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: February 10, 2003
Accepted: September 11, 2003
Published online: December 08, 2003
Issue release date: December 2003

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 6

ISSN: 1010-4283 (Print)
eISSN: 1423-0380 (Online)

For additional information: http://www.karger.com/TBI


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