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Table of Contents
Vol. 65, No. 3, 2003
Issue release date: December 2003
Section title: Clinical Study
Oncology 2003;65:218–223
(DOI:10.1159/000074474)

Phase II Study of Gemcitabine plus Docetaxel in Advanced Pancreatic Cancer: A Hoosier Oncology Group Study

Schneider B.P.a · Ganjoo K.N.a · Seitz D.E.a · Picus J.c · Fata F.d · Stoner C.a · Calley C.b · Loehrer P.J.a
Divisions of aHematology-Oncology and bBiostatistics, Indiana University Medical Center and Walther Cancer Institute, Indianapolis, Ind.; cWashington University School of Medicine, St.Louis,Mo.; dCancerTreatmentCentersof America at Goshen Health Center, Goshen, Ind., USA

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: February 26, 2003
Published online: December 05, 2003
Issue release date: December 2003

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Objective: To determine the response rate, duration of response and survival with weekly gemcitabine plus docetaxel in metastatic or unresectable pancreatic cancer. Methods: Forty patients were enrolled, and 38 patients were evaluable for survival and toxicity. Thirty-seven patients were evaluable for response. Nine patients (24%) had locally advanced disease and 29 (76%) had metastatic disease at the time of enrollment. Median Eastern Cooperative Oncology Group performance status was 1. Patients received gemcitabine 750 mg/m2 i.v. and docetaxel 35 mg/m2 i.v. weekly for 3 out of 4 weeks for a maximum of 6 cycles. Results: Patients received a median of 4 cycles (range 1–6) of chemotherapy. An objective response was obtained in 10 patients (27%) with a median duration of 17 weeks. Median survival was 7 months, and 1-year survival was 19.3%. Eight patients experienced at least one form of grade 4 toxicity and 27 patients experienced at least one type of grade 3 toxicity. Conclusions: The combination of gemcitabine and docetaxel is a well-tolerated regimen with clinical efficacy. The ultimate role of this combination versus single-agent gemcitabine can only be determined by a randomized phase III trial.

© 2003 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: February 26, 2003
Published online: December 05, 2003
Issue release date: December 2003

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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