Amyotrophic lateral sclerosis is a neurological disorder that selectively affects motor neurons of brain and spinal cord. Emerging evidence indicates an involvement of the serine/threonine-cyclin-dependent kinase 5 (Cdk5) in the pathogenesis. Deregulation of Cdk5 by its truncated co-activators, p25 and p29, contributes to neurodegeneration by altering the phosphorylation state of cytosolic and cytoskeletal proteins and, possibly, through the induction of cell cycle regulators. The present paper reviews these findings and proposes new perspectives to decipher the mechanisms of neurodegeneration in amyotrophic lateral sclerosis induced by Cdk5.
© 2003 S. Karger AG, Basel
Minh Dang Nguyen, PhD
Dept. of Pathology, Harvard Medical School
200 Longwood Ave., Armenise Bldg., D1-342
Boston, MA 02115 (USA)
Tel. +1 617 432 0320, Fax +1 617 432 3975
Jean-Pierre Julien, PhD
CHUL Research Center, Laval University
2705 Boulevard Laurier
Sainte-Foy, Que. G1V 4G2 (Canada)
Received: April 10, 2003
Accepted after revision: May 13, 2003
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 0, Number of References : 47
Founded 1992 as ‘Biological Signals’ by S.F. Pang (1992–2001) continued as ‘Biological Signals and Receptors’ (1999–2001)
Vol. 12, No. 4-5, Year 2003 (Cover Date: September-October 2003)
Journal Editor: Nancy Y. Ip, Hong Kong
ISSN: 1424–862X (print), 1424–8638 (Online)
For additional information: http://www.karger.com/journals/nsg
Article / Publication Details
Published online: 12/18/2003
Issue release date: September–October 2003
Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 0
ISSN: 1424-862X (Print)
eISSN: 1424-8638 (Online)
For additional information: http://www.karger.com/NSG
Copyright / Drug Dosage
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.