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Table of Contents
Vol. 17, Suppl. 1, 2004
Issue release date: December 2003
Section title: Paper
Dement Geriatr Cogn Disord 2004;17(suppl 1):40–48
(DOI:10.1159/000074681)

Efficacy and Safety of Galantamine in Patients with Dementia with Lewy Bodies: A 12-Week Interim Analysis

Edwards K.R.a · Hershey L.b · Wray L.b · Bednarczyk E.M.c · Lichter D.b · Farlow M.d · Johnson S.e
aAlzheimer’s Diagnostic and Treatment Center, Neurological Research Center, Bennington, Vt., and Harvard Medical School, Boston, Mass.; bBuffalo Veterans Affairs Hospital, Department of Neurology; cUniversity at Buffalo, Department of Nuclear Medicine, Buffalo, N.Y.; dDepartment of Neurology, Indiana University School of Medicine, Indianapolis, Ind.; eDepartment of Mathematics, Williams College, Williamstown, Mass., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: December 19, 2003
Issue release date: December 2003

Number of Print Pages: 9
Number of Figures: 9
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Observations on the neurochemistry of dementia with Lewy bodies (DLB) have suggested that cholinesterase inhibitors (ChEIs) might be beneficial in treating some clinical symptoms of DLB. A 24-week, multicenter open-label study was designed to assess the safety and efficacy of the ChEI galantamine in patients with DLB, and an interim analysis of results was performed at 12 weeks. Efficacy analyses were performed on data from 25 patients. Scores on the Neuropsychiatric Inventory (NPI-12) improved (decreased) by 7.52 points over the 12 weeks (marginally significant, p = 0.061). NPI-12 scores decreased by half in 12 of the 25 patients. Highly significant improvement was observed in scores on the NPI-4 subscale (delusions, hallucinations, apathy, and depression: p = 0.003). Scores on the Clinician’s Global Impression of Change (CGIC) improved by 0.95 points (significant, p = 0.02). Improvements also were found in secondary efficacy variables, including cognitive, functional, activities of daily living, sleep and confusion assessments. Motor scores, as measured by the UPDRS motor subscale, showed mild improvement, which demonstrates that galantamine has no adverse effect on parkinsonian symptoms. Adverse events generally were transient and of mild-to-moderate intensity. Two of the 25 patients discontinued galantamine because of nausea and anorexia. One serious adverse event was recorded, but it was judged to be unrelated to the study medication.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: December 19, 2003
Issue release date: December 2003

Number of Print Pages: 9
Number of Figures: 9
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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