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Vol. 10, No. 5, 2003
Issue release date: October 2003
Section title: Original Article · Originalarbeit
Forsch Komplementärmed Klass Naturheilkd 2003;10:242–247
(DOI:10.1159/000074778)

Wirksamkeit von Arnica bei Varizenoperation: Ergebnisse einer randomisierten, doppelblinden, Placebo-kontrollierten Pilot-Studie

Wolf M. · Tamaschke C. · Mayer W. · Heger M.
aPraxis für Homöopathie, Berlin-Karow; bPraxis für Gefässerkrankungen, Berlin-Buch; cClinical Study Monitoring, Walldorf-Heidelberg; dForschungszentrum HomInt, Karlsruhe, Deutschland

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Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: 11/7/2003

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-4119 (Print)
eISSN: 1661-4127 (Online)

For additional information: http://www.karger.com/FOK

Abstract

Efficacy of Arnica in Varicose Vein Surgery: Results of a Randomized, Double-Blind, Placebo-Controlled Pilot Trial Introduction: In homeopathy Arnica is widely used as a woundhealing medication and for the treatment of hematomas. Objective: In this pilot study the efficacy and safety of Arnica D12 in patients following varicose vein surgery were investigated. Design: Prospective, randomized, double-blind, placebo-controlled pilot trial according to ICH GCP guidelines. Setting: The study was conducted by a surgeon at the Angiosurgical Clinic, Berlin- Buch. Intervention: After randomized allocation, 60 patients received either Arnica D12 or placebo. Start of medication occurred the evening before operation with 5 globules. On the operation day one preoperative and hourly postoperative dosages after awakening were given. On days 2–14 of the study 5 globules 3 times a day were given. Outcome Criteria: Surface (in cm² and using a three-point verbal rating scale) and intensity of hematomas induced by operation, complications of wound healing, and intensity of pain (five-point verbal rating scale) as well as efficacy and safety of the study medication were assessed. Results: Hematoma surface was reduced (from day 7 to day 14) under Arnica by 75.5% and under placebo by 71.5% (p = 0.4726). The comparison of hematoma surface (small, medium, large) using the verbal rating scale yielded a value of p = 0.1260. Pain score decreased by 1.0 ± 2.2 points under Arnica and 0.3 ± 0.8 points under placebo (p = 0.1977). Remission or improvement of pain was observed in 43.3% of patients in the Arnica group and in 27.6% of patients in the placebo group. Tolerability was rated as very good in all cases. Conclusion: The results of this pilot study showed a trend towards a beneficial effect of Arnica D12 with regard to reduction of hematoma and pain during the postoperative course. For a statistically significant proof of efficacy of Arnica D12 in patients following varicose vein surgery a larger sample size is necessary.


  

Publication Details

Forschende Komplementärmedizin und Klassische Naturheilkunde / Research in Complementary and Classical Natural Medicine
Offizielles Organ der Schweizerischen Medizinischen Gesellschaft für Phytotherapie, European Society for Classical Natural Medicine

Vol. 10, No. 5, Year 2003 (Cover Date: October 2003)

Journal Editor: H. Walach, Freiburg i.Br., Germany
ISSN: 1424–7364 (print), 1424–7372 (Online)

For additional information: http://www.karger.com/fkm


Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: 11/7/2003

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-4119 (Print)
eISSN: 1661-4127 (Online)

For additional information: http://www.karger.com/FOK


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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