The Ischemic Penumbra: Identification, Evolution and Treatment ConceptsFisher M.
Department of Neurology, University of Massachusetts Medical School, Worcester, Mass., USA
The concept of the ischemic penumbra is an important one for both basic investigators of cerebral ischemia and for clinicians who treat stroke patients. The ischemic penumbra has been defined in a variety of ways, but the most clinically relevant definition is that portion of the ischemic territory that is still potentially salvageable, if an appropriate treatment is given. Currently, three main challenges persist for those interested in the ischemic penumbra concept: how can this ischemic region be most accurately identified in stroke patients, what mechanisms of ischemic cell death are most important for progression from penumbra towards irreversible injury and what therapeutic modalities are most likely to impede the development of infarction? Much important information regarding each of these topics has become available recently and will be the focus of this paper.
Marc Fisher, MD
Department of Neurology, University of Massachusetts Medical School
119 Belmont Street
Worcester, MA 01605 (USA)
Tel. +1 508 334 6641, Fax +1 508 334 6695, E-Mail FisherM@ummhc.org
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 4, Number of References : 35
Cerebrovascular Diseases (Official Journal of the European Stroke Council)
Vol. 17, No. Suppl. 1, Year 2004 (Cover Date: Released December 2003)
Journal Editor: J. Bogousslavsky, Lausanne; M.G. Hennerici, Mannheim
ISSN: 1015–9770 (print), 1421–9786 (Online)
For additional information: http://www.karger.com/journals/ced