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Table of Contents
Vol. 85, No. 1, 2004
Issue release date: March 2004
Section title: Original Paper
Biol Neonate 2004;85:11–14
(DOI:10.1159/000074951)

Inter- and Intraobserver Agreement for Gastroesophageal Reflux Detection in Infants Using Multiple Intraluminal Impedance

Peter C.S.a · Sprodowski N.a · Ahlborn V.a · Wiechers C.a · Schlaud M.b · Silny J.c · Poets C.F.d
Departments of aPediatric Pulmonary and Neonatology and bEpidemiology, Social Medicine, and Health System Research, Hannover Medical School, Hannover, cHelmholtz Institute, Technical University of Aachen, Aachen, and dDepartment of Neonatology, University of Tübingen, Tübingen, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 17, 2003
Published online: March 12, 2004
Issue release date: March 2004

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

The multiple intraluminal impedance (MII) technique is a new method that allows pH-independent gastroesophageal reflux detection via changes in impedance caused by a liquid bolus inside the esophagus. We wanted to know whether this technique yields objective and reproducible results. Twenty 3- to 6-hour recordings of MII from 19 preterm infants (median gestational age at birth 30 weeks, range 24–34 weeks; age at study 26 days, range 13–93 days) were divided into 23-second segments and analyzed for reflux episodes by three investigators; one investigator analyzed the data set twice. Observer agreement was assessed using kappa statistics. Each investigator analyzed 16,627 23-second segments, with a median of 854 (range 486–979) segments per recording. Median kappa values for the 20 recordings were 0.79, 0.83, and 0.83 for the three pairs of investigators and 0.84 for the repeated scoring procedure. MII recordings could be analyzed with a high level of inter- and intraobserver agreement.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 17, 2003
Published online: March 12, 2004
Issue release date: March 2004

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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