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Table of Contents
Vol. 85, No. 1, 2004
Issue release date: March 2004
Section title: Original Paper
Biol Neonate 2004;85:61–67
(DOI:10.1159/000074960)

Transient Decrease in the CD45RA Expression on T Lymphocytes in Neonates with Fetal Distress

Mizobe N. · Sugita K. · Tezuka T. · Sakamoto M. · Fukada Y. · Hoshi K. · Nakazawa S.
Departments of aPediatrics, bClinical and Laboratory Medicine, and cObstetrics and Gynecology, Faculty of Medicine, University of Yamanashi, Yamanashi, and dDivision of Neonatology, Perinatal Center, YamanashiPrefectural Central Hospital, Yamanashi, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/24/2003
Published online: 3/12/2004

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

To determine the expression of CD45 isoforms on T lymphocytes in neonates with fetal distress and to evaluate its diagnostic accuracy, peripheral blood samples were examined in 53 neonates who were classified into one of three groups: group I: ‘control’ group (n = 23), group II: ‘mild distress’ group (n = 15), and group III: ‘moderate distress’ group (n = 15). The expression of CD3 (mean ± SD 24.2 ± 10.1%), CD4 (23.0 ± 5.7%), and CD45RA (27.3 ± 9.6%) on total lymphocytes and the expression of CD45RA on CD4+ T lymphocytes (13.7 ± 4.7%) in group III were significantly lower than in the other two groups 0–3 days after birth. Sensitivity and specificity of the CD45RA expression on CD4+ T lymphocytes for discrimination of group III were calculated as 0.79 and 1.0, respectively, when the cutoff value was 22.7%. The low CD3, CD4, and CD45RA expression returned to normal levels 10 days and more after birth. There were no differences in the CD8 and CD45RO expression between the groups. We conclude that CD4+ T lymphocytes from neonates with fetal distress show a transient decrease in the CD45RA expression without an increase in the CD45RO expression, and, therefore, analysis of the CD45 isoform expression is useful for laboratory evaluation of fetal distress.


  

Author Contacts

Kanji Sugita
Department of Pediatrics, Faculty of Medicine, University of Yamanashi
1110 Shimokato, Tamaho-cho, Nakakoma-gun
Yamanashi 409-3898 (Japan)
Tel. +81 55 273 9606, Fax +81 55 273 6745, E-Mail ksugita@res.yamanashi-med.ac.jp

  

Article Information

Received: April 24, 2003
Accepted: July 24, 2003
Published online: November 19, 2003
Number of Print Pages : 7
Number of Figures : 4, Number of Tables : 2, Number of References : 27

  

Publication Details

Biology of the Neonate (Foetal and Neonatal Research)

Vol. 85, No. 1, Year 2004 (Cover Date: Released March 2004)

Journal Editor: J.P. Relier, Paris
ISSN: 0006–3126 (print), 1421–9727 (Online)

For additional information: http://www.karger.com/bon


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/24/2003
Published online: 3/12/2004

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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