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Table of Contents
Vol. 208, No. 1, 2004
Issue release date: July 2004
Section title: Pharmacology and Treatment
Dermatology 2004;208:43–48
(DOI:10.1159/000075045)

Interferon Alpha as Adjuvant Postsurgical Treatment of Melanoma: A Meta-Analysis

Pirard D.a · Heenen M.a · Melot C.b · Vereecken P.a
aDepartment of Dermatology and bIntensive Care, Erasme Hospital, Brussels, Belgium

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Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Received: April 01, 2003
Accepted: July 29, 2003
Published online: February 03, 2004
Issue release date: July 2004

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: The literature on the benefit of α-interferon (IFN-α) as adjuvant postsurgical treatment of melanoma reports discordant results. Objective: With the published data so far, we performed a meta-analysis in order to evaluate the effect of IFN-α on the relapse rate (RR) and the overall survival (OS). Methods: Published randomised trials were identified by Medline search. Stage IV melanoma was not considered. Results: Nine published studies were included, with a total of 2,880 patients. Both the per protocol and the intention-to-treat analysis show that IFN-α significantly decreased the RR (OR = 0.74; 95% CI = 0.64–0.86). Subgroup analyses show that, for all stages, high and low doses decreased the RR (OR = 0.71, 95% CI = 0.54–0.92, and OR = 0.76, 95% CI = 0.63–0.91, respectively). No difference has been evidenced on OS. Conclusions: High and low doses of IFN-α significantly decrease the RR, but the OS does not seem to be improved.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Received: April 01, 2003
Accepted: July 29, 2003
Published online: February 03, 2004
Issue release date: July 2004

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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