Interferon Alpha as Adjuvant Postsurgical Treatment of Melanoma: A Meta-AnalysisPirard D. · Heenen M. · Melot C. · Vereecken P.
aDepartment of Dermatology and bIntensive Care, Erasme Hospital, Brussels, Belgium
Background: The literature on the benefit of α-interferon (IFN-α) as adjuvant postsurgical treatment of melanoma reports discordant results. Objective: With the published data so far, we performed a meta-analysis in order to evaluate the effect of IFN-α on the relapse rate (RR) and the overall survival (OS). Methods: Published randomised trials were identified by Medline search. Stage IV melanoma was not considered. Results: Nine published studies were included, with a total of 2,880 patients. Both the per protocol and the intention-to-treat analysis show that IFN-α significantly decreased the RR (OR = 0.74; 95% CI = 0.64–0.86). Subgroup analyses show that, for all stages, high and low doses decreased the RR (OR = 0.71, 95% CI = 0.54–0.92, and OR = 0.76, 95% CI = 0.63–0.91, respectively). No difference has been evidenced on OS. Conclusions: High and low doses of IFN-α significantly decrease the RR, but the OS does not seem to be improved.
Delphine Pirard, MD
Hôpital Universitaire Erasme
Route de Lennik 808
BE–1070 Brussels (Belgium)
Tel. +32 2555 31 11, Fax +32 2762 86 34, E-Mail firstname.lastname@example.org
Received: April 14, 2003
Accepted: July 29, 2003
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 1, Number of References : 28
Dermatology (International Journal for Clinical and Investigative Dermatology)
Founded as ‘Dermatologische Zeitschrift’ by Oskar Lassar (1893–1907); Continued by Erich Hoffmann (1908–1938), continued as ‘Dermatologica’ (1939–1991), by Wilhelm Lutz (1939–1958), Rudolf Schuppli (1959–1985)
Official Organ of the Swiss Society for Dermatology and Venereology; Official Organ of the Belgian Royal Society for Dermatology and Venereology
Vol. 208, No. 1, Year 2004 (Cover Date: 2004)
Journal Editor: J.-H. Saurat, Geneva.
ISSN: 1018–8665 (print), 1421–9832 (Online)
For additional information: http://www.karger.com/journals/drm