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Table of Contents
Vol. 70, No. 6, 2003
Issue release date: November–December 2003
Section title: Review
Respiration 2003;70:665–671
(DOI:10.1159/000075218)

Inflammation and Obstructive Sleep Apnea Syndrome Pathogenesis: A Working Hypothesis

Hatipoğlu U. · Rubinstein I.
Section of Respiratory and Critical Care Medicine, Department of Medicine, University of Illinois at Chicago and VA Chicago Health Care System, Chicago, Ill., USA

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: 6/25/2003
Accepted: 7/9/2003
Published online: 1/16/2004

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES

Abstract

Obstructive sleep apnea syndrome (OSAS) afflicts about 5% of adults in Western countries and is thought to play an important role in the pathogenesis of cardiovascular disorders and diabetes mellitus. Although the etiology of OSAS is uncertain, intense local and systemic inflammation are present in these patients. In the upper airway, this process may promote oropharyngeal inspiratory muscle dysfunction and amplify upper airway narrowing and collapsibility thereby worsening the frequency and duration of apneas during sleep. The presence of systemic inflammation, characterized by elevated levels of certain potent pro-inflammatory mediators, such as C-reactive protein, leptin, TNF-α, IL-1β, IL-6, reactive oxygen species and adhesion molecules, may predispose to the development of cardiovascular complications observed in patients with OSAS. Treatment with nasal CPAP abrogates, in part, local and systemic inflammation in these patients. Whether therapeutic interventions aimed at abating inflammation could be a useful adjunct in the treatment of OSAS merits further investigation.


  

Author Contacts

Prof. Israel Rubinstein, MD
Department of Medicine (M/C 719), University of Illinois at Chicago
Building 911, Room 173, 840 South Wood Street
Chicago, IL 60616-7323 (USA)
Tel. +1 312 996 8039, Fax +1 312 996 4665, E-Mail IRubinst@uic.edu

  

Article Information

Received: June 25, 2003
Accepted: September 7, 2003
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 0, Number of References : 48

  

Publication Details

Respiration (International Review of Thoracic Diseases)
Founded 1944 as ‘Schweizerische Zeitschrift für Tuberkulose und Pneumonologie’ by E. Bachmann, M. Gilbert, F. Häberlin, W. Löffler, P. Steiner and E. Uehlinger, continued 1962–1967 as ‘Medicina Thoracalis’ as of 1968 as ‘Respiration’, H. Herzog (1962–1997)
Official Journal of the European Association for Bronchology and Interventional Pulmonology

Vol. 70, No. 6, Year 2003 (Cover Date: November-December 2003)

Journal Editor: C.T. Bolliger, Cape Town
ISSN: 0025–7931 (print), 1423–0356 (Online)

For additional information: http://www.karger.com/journals/res


Article / Publication Details

First-Page Preview
Abstract of Review

Received: 6/25/2003
Accepted: 7/9/2003
Published online: 1/16/2004

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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