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Vol. 49, No. 1, 2004
Issue release date: January 2004
Section title: Biological Psychiatry. Editor: J. Mendlewicz (Brussels) / Original Paper
Neuropsychobiology 2004;49:10–12
(DOI:10.1159/000075332)

Association Analysis of Brain-Derived Neurotrophic Factor Val66Met Polymorphisms with Alzheimer’s Disease and Age of Onset

Tsai S.-J. · Hong C.-J. · Liu H.-C. · Liu T.-Y. · Hsu L.-E. · Lin C.-H.
Departments of aPsychiatry and bMedical Research and Education, and cNeurological Institute, Taipei Veterans General Hospital, and dDivision of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, and eKai-Suan Psychiatric Hospital, Kaohsiung, Taiwan, ROC

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Editor: J. Mendlewicz (Brussels) / Original Paper

Published online: 1/22/2004

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

Because of a decrease in central brain-derived neurotrophic factor (BDNF) levels in Alzheimer’s disease (AD) and the important role of BDNF in neuronal survival, BDNF may represent a candidate gene conferring susceptibility to AD. Recently, a functional BDNF Val66Met polymorphism has been associated with AD in an Italian population. In the present study, we investigated a possible role of this BDNF polymorphism in the susceptibility of AD or AD onset in a Chinese population. Comparing AD patients and controls, the distribution of the BDNF genotypes and alleles did not differ significantly. The onset age was not significantly different comparing the three BDNF genotype groups. Our negative findings suggest that it is unlikely that the BDNF Val66Met polymorphism plays a major role in the pathogenesis of AD in the Chinese population and do not support previous findings that homozygosity for the 66Val allele confers an increased risk for AD. Further studies with genetic variations in BDNF relating either to AD-associated depression or to the AD treatment response are suggested.


  

Author Contacts

Shih-Jen Tsai, MD
Department of Psychiatry, Taipei Veterans General Hospital
201, Shih-Pai Road, Sec. 2
Taipei 11217, Taiwan (ROC)
Tel. +886 2 2875 7027 ext. 276, Fax +886 2 2872 5643, E-Mail sjtsai@vghtpe.gov.tw

  

Article Information

The experiments in this study were performed in the Molecular Genetic Laboratory, Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Number of Print Pages : 3
Number of Figures : 0, Number of Tables : 1, Number of References : 14

  

Publication Details

Neuropsychobiology
Founded 1975 by J. Mendlewicz (Brussels)
Official Journal of the International Pharmaco-EEG Society (IPEG)

Vol. 49, No. 1, Year 2004 (Cover Date: Released January 2004)

Journal Editor: P. Netter, Giessen; J. Mendlewicz, Brussels; B. Saletu, Vienna
ISSN: 0302–282X (print), 1423–0224 (Online)

For additional information: http://www.karger.com/nps


Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Editor: J. Mendlewicz (Brussels) / Original Paper

Published online: 1/22/2004

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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