Association Study of a Brain-Derived Neurotrophic Factor (BDNF) Val66Met Polymorphism and Personality Trait and Intelligence in Healthy Young FemalesTsai S.-J. · Hong C.-J. · Yu Y.W.-Y. · Chen T.-J.
aDepartment of Psychiatry, Taipei Veterans General Hospital, and bDivision of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, cYu’s Psychiatric Clinic and dKai-Suan Psychiatric Hospital, Kaohsiung, Taiwan, ROC
Brain-derived neurotrophic factor (BDNF), a member of the nerve-growth-factor family, plays an important role in neuronal survival and development, and it can modulate serotonergic activity. Further, BDNF has been implicated in the expression of personality traits and in cognitive function. We tested the associations between functional BDNF Val66Met genetic variants, and personality trait and intelligence in a cohort of 114 healthy young Chinese females. Subjects with the Val/Val genotype had a significantly higher mean performance IQ than Val/Met carriers, especially for the Object Assembly subtest. No significant association was demonstrated for the BDNF polymorphism and any of the Tridimensional Personality Questionnaire personality-factor scores, including harm avoidance. These results suggest that genetic variants of the BDNF gene may play a role in specific cognitive functions, but not in overall intelligence. In contrast to a recent report, however, this polymorphism does not appear to be associated with the neuroticism-related personality trait.
Shih-Jen Tsai, MD
Department of Psychiatry, Taipei Veterans General Hospital
201, Shih-Pai Road, Sec. 2
Taipei 11217, Taiwan (ROC)
Tel. +886 2 2875 7027 ext. 276, Fax +886 2 2872 5643, E-Mail firstname.lastname@example.org
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 1, Number of References : 24
Founded 1975 by J. Mendlewicz (Brussels)
Official Journal of the International Pharmaco-EEG Society (IPEG)
Vol. 49, No. 1, Year 2004 (Cover Date: Released January 2004)
Journal Editor: P. Netter, Giessen; J. Mendlewicz, Brussels; B. Saletu, Vienna
ISSN: 0302–282X (print), 1423–0224 (Online)
For additional information: http://www.karger.com/nps