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Table of Contents
Vol. 49, No. 1, 2004
Issue release date: January 2004
Section title: Biological Psychiatry. Editor: J. Mendlewicz (Brussels) / Original Paper
Neuropsychobiology 2004;49:38–41
(DOI:10.1159/000075337)

Association between Major Depressive Disorder and the –1438A/G Polymorphism of the Serotonin 2A Receptor Gene

Choi M.-J.a,b · Lee H.-J.a · Lee H.-J.b · Ham B.-J.c · Cha J.-H.a · Ryu S.-H.d · Lee M.-S.a
Departments of aPsychiatry, Korea University College of Medicine, bMedical Sciences, Korea University Graduate School, cYong-In Psychiatric Research Institute, and dPsychiatry, Konkuk University Medical College, Seoul, Korea

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Editor: J. Mendlewicz (Brussels) / Original Paper

Published online: January 22, 2004
Issue release date: January 2004

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

This study investigated the possible effect of the –1438A/G single-nucleotide polymorphism in the promoter region of the serotonin 2A receptor (5-HTR2A) gene on major depressive disorder (MDD) in a Korean population. This polymorphism was analyzed in 189 patients with MDD and in 148 unrelated healthy controls using a case-control design, which revealed a significant difference in the genotype distributions (χ2 = 10.78, d.f. = 2, p = 0.005). The frequency of the –1438G allele was also much higher in MDD patients than in normal controls (χ2 = 7.20, p = 0.007; OR = 1.52, 95% CI 1.12–2.06). We also found significantly more carriers of the G allele (GG+AG genotypes) in MDD patients than in normal controls (χ2 = 10.18, p = 0.001; OR = 2.46, 95% CI 1.40–4.32). Our results support the hypothesis that the –1438A/G polymorphism of the promoter region of the 5-HTR2A gene is associated with MDD patients in a Korean population.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Editor: J. Mendlewicz (Brussels) / Original Paper

Published online: January 22, 2004
Issue release date: January 2004

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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