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Table of Contents
Vol. 61, No. 3, 2004
Issue release date: March 2004
Section title: Original Paper
Horm Res 2004;61:133–136
(DOI:10.1159/000075588)

Normal Bone Mineral Content in Young Adults with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

Christiansen P.a · Mølgaard C.b,c · Müller J.a
aDepartment of Growth and Reproduction, Section GR-5064, Rigshospitalet, Copenhagen, bDepartment of Human Nutrition and Centre for Advanced Food Studies, Danish Veterinary and Agricultural University, Frederiksberg, and cPaediatric Nutrition Unit, The Juliane Marie Center, Rigshospitalet, Copenhagen, Denmark

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 23, 2003
Accepted: October 13, 2003
Published online: March 17, 2004
Issue release date: March 2004

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Objective: To assess bone mineral content (BMC) and body composition in adolescents and young adults with congenital adrenal hyperplasia. Methods: BMC, anteroposterior-projected bone area (BA), bone mineral density, and fat mass percentage were determined by dual-energy X-ray absorptiometry in 18 patients aged 18–33 years (8 females and 10 males) with 21-hydroxylase deficiency using a Hologic QDR 1000/W densitometer. Results: BMC and bone mineral density for age were significantly reduced at –1.2 standard deviation scores (SDS; range from –2.8 to +4.1) and –1.1 SDS (range from –3.2 to +2.6), respectively. The BA for height was significantly increased at +1.7 SDS (range from –0.5 to +4.8), and the BMC for BA was normal at 0.3 SDS (range from –2.0 to +3.6). The median final height was significantly reduced at –1.6 SDS (range from –5.6 to +0.3), and the fat mass percentage was significantly increased at +1.5 SDS (range from –1.0 to +5.0). Conclusion: Our study population of young adults with 21-hydroxylase deficiency had a short stature and broad bones with a normal BMC and had an increased fat mass percentage.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 23, 2003
Accepted: October 13, 2003
Published online: March 17, 2004
Issue release date: March 2004

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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