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Vol. 57, No. 3, 2004
Issue release date: March 2004
Section title: Original Article
Gynecol Obstet Invest 2004;57:121–126
(DOI:10.1159/000075701)

The Role of c-Jun Protein in Proliferation and Apoptosis of the Endometrium throughout the Menstrual Cycle

Udou T. · Hachisuga T. · Tsujioka H. · Kawarabayashi T.
Department of Obstetrics and Gynecology, Fukuoka University School of Medicine, Fukuoka, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: 1/9/2003
Accepted: 11/12/2003
Published online: 4/2/2004
Issue release date: March 2004

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 2

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

Proliferation and apoptosis of the endometrium throughout the menstrual cycle were evaluated. Sections from 30 premenopausal women were examined using antibodies of c-jun protein, c-fos protein, estrogen receptors alpha and beta (ER-α and ER-β), progesterone receptor (PR), and Ki-67. Apoptotic cells were identified using a modified terminal deoxynucleotidyl-transferase-mediated biotinylated deoxyuridine triphosphate nick-end labeling (TUNEL) method. The cyclic changes of c-jun protein, c-fos protein, ER-α, PR, and Ki-67 were shown in glandular epithelial cells. Although the stromal expression of ER-α decreased during the secretory phase, a high stromal expression of c-jun protein and PR was still observed during the late secretory phase. The expression of ER-β appeared lower as compared with that of ER-α, without a cyclic change. The apoptotic index was significantly elevated in the glandular epithelial cells of the late secretory phase, whereas a few apoptotic cells were detected in the stromal cells at any stage of the cycle. The cyclic change of c-jun protein probably plays an important role in proliferation and apoptosis of glandular epithelial cells. The persistent stromal expression of c-jun protein and PR is thus considered to prevent stromal cells from entering into apoptosis during the late secretory phase.

© 2004 S. Karger AG, Basel


  

Author Contacts

Toru Hachisuga, MD
Department of Obstetrics and Gynecology, Fukuoka University School of Medicine
45-1, 7-chome, Nanakuma, Jonan-ku
Fukuoka 814-0180 (Japan)
Tel. +81 92 801 1101, Fax +81 92 865 4114, E-Mail hachisug@fukuoka-u.ac.jp

  

Article Information

Received: January 9, 2003
Accepted after revision: November 11, 2003
Published online: December 23, 2003
Number of Print Pages : 6
Number of Figures : 4, Number of Tables : 2, Number of References : 20

  

Publication Details

Gynecologic and Obstetric Investigation
Founded 1895 as ‘Monatsschrift für Geburtshilfe und Gynäkologie’, continued 1946–1969 as ‘Gynaecologia’ and 1970 –1977 as ‘Gynecologic Investigation’

Vol. 57, No. 3, Year 2004 (Cover Date: Released March 2004)

Journal Editor: T.M. D'Hooghe, Leuven; J. Yankowitz, Iowa City, Iowa
ISSN: 0378–7346 (print), 1423–002X (Online)

For additional information: http://www.karger.com/journals/goi


Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: 1/9/2003
Accepted: 11/12/2003
Published online: 4/2/2004
Issue release date: March 2004

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 2

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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