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Table of Contents
Vol. 102, No. 1-4, 2003
Issue release date: 2003
Section title: Paper
Cytogenet Genome Res 102:254–260 (2003)
(DOI:10.1159/000075758)

A canine cancer-gene microarray for CGH analysis of tumors

Thomas R.a,b · Fiegler H.c · Ostrander E.A.d · Galibert F.e · Carter N.P.c · Breen M.b
aOncology Research Group, Centre for Preventive Medicine, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk (UK); bDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC (USA); cThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge (UK); dClinical Research and Human Biology Divisions, Fred Hutchinson Cancer Research Center, Seattle WA (USA); eUMR 6061 CNRS, Génétique et développement, Faculté de Médecine, Rennes (France)

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: March 01, 2004
Issue release date: 2003

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

As with many human cancers, canine tumors demonstrate recurrent chromosome aberrations. A detailed knowledge of such aberrations may facilitate diagnosis, prognosis and the selection of appropriate therapy. Following recent advances made in human genomics, we are developing a DNA microarray for the domestic dog, to be used in the detection and characterization of copy number changes in canine tumors. As a proof of principle, we have developed a small-scale microarray comprising 87 canine BAC clones. The array is composed of 26 clones selected from a panel of 24 canine cancer genes, representing 18 chromosomes, and an additional set of clones representing dog chromosomes 11, 13, 14 and 31. These chromosomes were shown previously to be commonly aberrant in canine multicentric malignant lymphoma. Clones representing the sex chromosomes were also included. We outline the principles of canine microarray development, and present data obtained from microarray analysis of three canine lymphoma cases previously characterized using conventional cytogenetic techniques.   

© 2003 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: March 01, 2004
Issue release date: 2003

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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