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Table of Contents
Vol. 102, No. 1-4, 2003
Issue release date: 2003
Section title: Paper
Cytogenet Genome Res 102:272–276 (2003)
(DOI:10.1159/000075762)

Radiation hybrid mapping of 304 novel microsatellites in the domestic cat genome

Menotti-Raymond M.a · David V.A.a · Agarwala R.b · Schäffer A.A.c · Stephens R.d · O’Brien S.J.a · Murphy W.J.e
aLaboratory of Genomic Diversity, National Cancer Institute, Department of Health and Human Services, Frederick, MD; bNLM/NCBI/IEB; cNLM/NCBI/CBB, National Institutes of Health, Department of Health and Human Services, Bethesda, MD; dAdvanced Biomedical Computing Center, National Cancer Institute, Department of Health and Human Services, Frederick,MD, and eLaboratory of Genomic Diversity, Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute, DepartmentofHealth and Human Services, Frederick, MD (USA)

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: May 28, 2003
Accepted: August 05, 2003
Published online: March 01, 2004
Issue release date: 2003

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Effective utilization of the domestic cat as an animal model for hereditary and infectious disease requires the development and implementation of high quality gene maps incorporating microsatellites and conserved coding gene markers. Previous feline linkage and radiation hybrid maps have lacked sufficient microsatellite coverage on all chromosomes to make effective use of full genome scans. Here we report the isolation and genomic mapping of 304 novel polymorphic repeat loci in the feline genome. The new loci were mapped in the domestic cat radiation hybrid panel using an automated fluorescent Taq-Man based assay. The addition of these 304 microsatellites brings the total number of microsatellites mapped in the feline genome to 580, and the total number of loci placed onto the RH map to 1,126. Microsatellites now span every autosome with an average spacing of roughly one polymorphic STR every five centimorgans, and full genome coverage of one marker every 2.7 megabases. These loci now provide a useful tool for undertaking full-genome scans to identify genes associated with phenotypes of interest, such as those relating to hereditary disease, coat color, patterning and morphology. These resources can also be extended to the remaining 36 species of the cat family for population genetic and evolutionary genomic analyses.   

© 2003 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: May 28, 2003
Accepted: August 05, 2003
Published online: March 01, 2004
Issue release date: 2003

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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