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Original Paper

Influence of the Substrate on the Reproducibility of the Hydrogen Breath Test to Measure the Orocecal Transit Time

Casellas F. · Malagelada J.-R.

Author affiliations

Digestive System Research Unit, Hospital General Vall d’Hebron, Barcelona, Spain

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Digestion 1998;59:696–702

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: November 12, 1998
Issue release date: November – December

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 0

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG

Abstract

Background: The H2 breath test is widely used for the measurement of the orocecal transit time (OCTT). However, its clinical applicability is limited by its suboptimal reproducibility. Aim: To investigate whether changes in the substrate for the H2 breath test improve its reliability for the measurement of the OCTT. Methods: 72 consecutive patients referred for measurement of the OCTT were studied. The breath test was performed twice, on consecutive days. One group of patients (‘lactulose + water’ group) received lactulose 13.3 g in water both days. Another group (‘lactulose + diet’) received lactulose 13.3 g in a liquid meal of 400 kcal. A third group (‘lactulose-lactitol’) received 13.2 g of lactulose the first day and 10 g lactitol the following day. The fourth group (‘lactitol + water’) received lactitol 10 g in water both days. Alveolar breath was sampled every 10 min for the next 3 h for H2 chromatography. Results: OCTT in the first and second day test for the groups ‘lactulose + water’, ‘lactulose + diet’ and ‘lactitol + water’ were similar. In these three groups, the values obtained on the first and second day did not differ from 0 and were also significantly correlated. However, the correlation and the mean coefficient of variation were better in group ‘lactulose + water’ than in the groups ‘lactulose + diet’ and ‘lactitol + water’. In group ‘lactulose-lactitol’ the results on both days were significantly correlated although the delta between matched values was different from 0 (p = 0.03). Conclusion: The meal substrate influences the variability of the OCTT. However, reproducibility of the test does not improve with the addition of a liquid meal.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: November 12, 1998
Issue release date: November – December

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 0

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


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