Background and Aims: Inoculation of Helicobacter felis into the murine stomach has been reported to induce chronic gastric inflammation and may be a model of Helicobacter pylori-induced chronic gastritis. In this study, to characterize H. felis-induced gastritis, the gastric production of interleukin-1β (IL-1β) and hepatocyte growth factor (HGF) was measured in mice. Methods: Gastric mucosal lesions were induced in H. felis-infected BALB/c mice by water-immersion stress. The severity score of gastric erosions per stomach was measured as the sum of the length of erosions. Gene expression of IL-1β and HGF were analyzed by Northern blot analysis and production of HGF was examined using the enzyme immunoassay method. Results: Water-immersion stress induced gastric mucosal lesions accompanied by increased expression of IL-1β mRNA. H. felis infection evoked enhanced expression of IL-1β and HGF genes. When H. felis-infected mice were stressed by water immersion, the mucosal lesions were more severe than those in non-infected mice. Moreover, IL-1β gene expression as well as HGF production was further increased. Conclusions: Although H. felis inoculation did not cause gastric mucosal erosions by itself, it augmented the stress-induced erosions.
Received: Received: September 1, 1997
Accepted: June 13, 1998
Number of Print Pages : 7
Number of Figures : 8, Number of Tables : 1, Number of References : 23
Digestion (International Journal of Gastroenterology)
Founded as Archiv für Verdauungskrankheiten, 1895; continued as Gastroenterologia, 1939-1967
Vol. 60, No. 1, Year 1999 (Cover Date: January-February 1999)
Journal Editor: R. Arnold, Marburg
ISSN: 0012–2823 (print), 1421–9867 (Online)
For additional information: http://www.karger.com/journals/dig
Article / Publication Details
Published online: 1/18/1999
Issue release date: January–February 1999
Number of Print Pages: 7
Number of Figures: 8
Number of Tables: 1
ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)
For additional information: http://www.karger.com/DIG
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