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Table of Contents
Vol. 23, No. 3, 2004
Issue release date: May – June
Section title: Original Paper
Neuroepidemiology 2004;23:144–149
(DOI:10.1159/000075958)

Review of Epidemiological Studies Searching for a Relationship between Onchocerciasis and Epilepsy

Druet-Cabanac M.a · Boussinesq M.b · Dongmo L.c · Farnarier G.d · Bouteille B.a · Preux P.M.a
aInstitute of Neuroepidemiology and Tropical Neurology EA 3174, Limoges, France; bInstitute of Research for Development, Yaoundé, and cDepartment of Neurology, Faculty of Medicine and Health Sciences, Yaoundé, Cameroon; dClinical Neurophysiology Service, North University Hospital Center, Marseille, France

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: April 16, 2004
Issue release date: May – June

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED

Abstract

A review and a meta-analysis of the available epidemiological literature for evidence of an association between onchocerciasis infection and epilepsy were carried out. We used EMBASE (1974–2002), MEDLINE (1966–2002), and PASCAL (1987–2002) databases and relevant journals and bibliographies. We limited our analysis to the epidemiological studies, where the status regarding onchocerciasis infection and epilepsy was available for each subject. Nine African studies were included. The common relative risk estimated by the random-effects model was 1.21 (95% CI 0.99–1.47; p = 0.06). The meta-analysis did not show any difference according to the onchocerciasis endemicity level and the African areas. Our results do not allow to conclude for an association between Onchocerca volvulus infection and epilepsy. However, the results are nearly significant. Further research is needed in this neglected subject, in particular for the better understanding of the neurological pathogenicity in onchocerciasis.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: April 16, 2004
Issue release date: May – June

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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