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Table of Contents
Vol. 57, No. 3, 2004
Issue release date: March 2004
Section title: Review
Gynecol Obstet Invest 2004;57:157–173
(DOI:10.1159/000076374)

The Link between Exposure to Dioxin and Endometriosis: A Critical Reappraisal of Primate Data

Guo S.-W.
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisc., USA

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: August 19, 2003
Accepted: November 12, 2003
Published online: April 02, 2004
Issue release date: March 2004

Number of Print Pages: 17
Number of Figures: 2
Number of Tables: 4

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

Endometriosis is a common and enigmatic disease affecting women of reproductive age. In 1993, Dr. Sherry Rier and her colleagues reported a serendipitous finding that quickly sent a shock wave through the endometriosis research community. They found that rhesus monkeys exposed daily for 4 years to dioxin developed endometriosis, with incidence and severity related to dose. The study prompted more animal and epidemiologic studies regarding the link between dioxin exposure and endometriosis. Yet, 10 years after the first piece of evidence was reported, the primate data are still equivocal, and the human data supporting the dioxin-endometriosis association are scanty and conflicting. While many reviewers of the subject recognize the need for more data, other reviewers tend to discount negative studies when reviewing positive studies. In this paper, a critical reappraisal of all evidence from human and primate data is presented. While there is evidence suggesting that exposure to dioxin may facilitate the short-term survival of endometrial implants in non-human primates, this evidence is not supported by both human and non-human primate studies evaluating the relationship between dioxin exposure and the development of spontaneous endometriosis. Weighing all converging evidence, it seems that there are no solid, credible data available at this moment to support the hypothesis that dioxin exposure may lead to the development of endometriosis.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Review

Received: August 19, 2003
Accepted: November 12, 2003
Published online: April 02, 2004
Issue release date: March 2004

Number of Print Pages: 17
Number of Figures: 2
Number of Tables: 4

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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