Paroxetine Decreases Respiratory Irregularity of Linear and Nonlinear Measures of Respiration in Patients with Panic Disorder
A Preliminary ReportYeragani V.K. · Rao R. · Tancer M. · Uhde T.
aDepartment of Psychiatry, Wayne State University School of Medicine, Detroit, Mich., USA; bDepartment of ECE, Indian Institute of Science, Bangalore, India
Previous studies indicate that serotonin reuptake inhibitors do not appear to have serious cardiac side effects. However, the effects of these agents on respiratory measures have not been studied in detail. Several studies indicate that patients with anxiety exhibit irregular breathing patterns as measured by tidal volume and respiratory rate. In this study, we evaluated the effects of a serotonin reuptake inhibitor, paroxetine, on respiratory variability in patients with panic disorder (n = 13), using linear and nonlinear measures of regularity, approximate entropy (APEN) and a measure of chaos, the largest Lyapunov exponent (LLE), with pre- and posttreatment lung volume time series (256 s long sampled at 4 Hz). Our results show that paroxetine significantly decreases some of the linear measures of variability and supine APEN and standing LLE of lung volume series after successful treatment. The implications of these findings on respiratory and cardiovascular function have been discussed.
Prof. V.K. Yeragani
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Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 2, Number of References : 43
Founded 1975 by J. Mendlewicz (Brussels)
Official Journal of the International Pharmaco-EEG Society (IPEG)
Vol. 49, No. 2, Year 2004 (Cover Date: Released February 2004)
Journal Editor: P. Netter, Giessen; J. Mendlewicz, Brussels; B. Saletu, Vienna
ISSN: 0302–282X (print), 1423–0224 (Online)
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