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Table of Contents
Vol. 111, No. 3, 2004
Issue release date: March 2004
Section title: Original Paper
Acta Haematol 2004;111:132–137
(DOI:10.1159/000076520)

Age-Dependent Changes in the Incidence and Etiology of Childhood Thrombocytosis

Matsubara K. · Fukaya T. · Nigami H. · Harigaya H. · Hirata T. · Nozaki H. · Baba K.
Department of Pediatrics, Nishi-Kobe Medical Center, Kobe, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 30, 2003
Accepted: October 02, 2003
Published online: March 26, 2004
Issue release date: March 2004

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

To determine the incidence and etiology of childhood thrombocytosis, over 15,000 platelet counts in 7,539 patients performed at a single regional hospital were reviewed. When thrombocytosis was defined as ≧500 × 109/l of platelet counts, the condition could be diagnosed in 6.0% (456 cases) of the patients. All patients were classified as having secondary thrombocytosis. The incidence of thrombocytosis dramatically changed throughout child development; it was 12.5% in neonates, peaked to 35.8% in 1-month-old infants and then returned to 12.9% in 6- to 11-month-old infants. Thereafter, it gradually decreased with age to only 0.6% in 11- to 15-year-old children. Frequent causes of thrombocytosis included infection (67.5%), Kawasaki disease (9.4%), prematurity (7.7%) and iron deficiency anemia (6.4%). Thrombocytosis was an incidental finding in a substantial population of early infants. Thrombocytosis as a reaction to several types of infection and Kawasaki disease was more common in children under 7 years old, while autoimmune disease and tissue damage were major causes in children aged 11–15 years. No child had thromboembolic complications. These findings indicate that childhood thrombocytosis is a benign condition and its incidence and etiology seem to depend on age.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 30, 2003
Accepted: October 02, 2003
Published online: March 26, 2004
Issue release date: March 2004

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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