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Neuronal Apoptosis in Neurodegenerative Diseases: From Basic Research to Clinical ApplicationKermer P. · Liman J. · Weishaupt J.H. · Bähr M.
Department of Neurology, University of Göttingen, Göttingen, Germany Corresponding Author
Dr. Pawel Kermer
Department of Neurology, University of Göttingen
DE–37075 Göttingen (Germany)
Tel. +49 551 394 927, Fax +49 551 391 4302, E-Mail email@example.com
In recent years, the investigation of erroneous regulation of apoptotic mechanisms during acute and chronic injury of neuronal cells has gained increasing attention. Besides acute neuronal trauma and ischemia, chronic neurodegenerative diseases like Alzheimer’s, Huntington’s, Parkinson’s and Lou-Gehrig’s disease (amyotrophic lateral sclerosis) are of particular interest. The present article will provide an overview of basic apoptotic mechanisms, the contribution of neuronal apoptosis to the above-mentioned disorders, potential clinical applications and their limitations and the possible implications for future studies regarding these neurodegenerative diseases.
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