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Table of Contents
Vol. 103, No. 3-4, 2003
Issue release date: 2003
Section title: Paper
Cytogenet Genome Res 103:235–244 (2003)
(DOI:10.1159/000076809)

Knockout mice provide novel insights into meiotic chromosome and telomere dynamics

Max-Planck-Institut für Molekulare Genetik, Berlin (Germany)

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: December 11, 1932
Accepted: December 15, 2003
Published online: March 30, 2004
Issue release date: 2003

Number of Print Pages: 10
Number of Figures: 2
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Meiosis is a succession of two specialized cell divisions that leads to the formation of gametes and thereby compensates for genome doubling at fertilization. During the extended prophase of the first meiotic division chromosomes assemble protein cores (axial elements) that attach their ends to the nuclear envelope. These ends transiently gather at a limited sector of the nuclear periphery (bouquet stage) at a time when meiotic recombination is initiated and when chromosomes initiate stable pairing (synapsis). This review discusses novel insights into the relation between recombinational DNA repair and meiotic telomere dynamics that have arrived from recent studies of transchromosomal mice and knockout mice. Analysis of mice deficient for A-type lamins, histone H2AX, Suv39h HMTases, and the AE protein SYCP3 suggests that entry into prophase I requires heterochromatin integrity and lamin A expression. Initiation of meiotic telomere clustering represents an early recombination-independent event in first meiotic prophase, while exit from the bouquet stage depends on signals that emanate from the progress of recombinational DNA repair as sensed by ATM kinase and relayed through histone H2AX.   

© 2003 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: December 11, 1932
Accepted: December 15, 2003
Published online: March 30, 2004
Issue release date: 2003

Number of Print Pages: 10
Number of Figures: 2
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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