The androgen receptor in spermatogenesisaGeorge H. Whipple Laboratory for Cancer Research, Departments of Pathology, Urology, and Radiation Oncology, University of Rochester, Rochester, New York (USA); bInstitute of Biotechnology and Department of Life Science, National Dong Hwa University, Hualien, cChang Gung Memorial Hospital in Kaohsiung and dInstitute of Medical Sciences and Department of Life Science, Tzu Chi University, Hualien (Taiwan)
Androgens are steroid hormones that are necessary for normal male phenotype expression, including the outward development of secondary sex characteristics as well as the initiation and maintenance of spermatogenesis. Many physiological actions of androgens are mediated by the androgen receptor (AR), a member of the nuclear receptor superfamily. AR functions as a ligand-dependent transcription factor, regulating expression of an array of target genes that are important in male pubertal development and fertility. In this review, the expression and necessity of AR in specific testicular cell types that are important in spermatogenesis will be discussed, and recent information obtained through the study of complete and cell type-specific AR null mouse models will be presented.
Request reprints from: Dr. C. Chang
George H. Whipple Laboratory for Cancer Research
Departments of Pathology, Urology, and Radiation Oncology
University of Rochester, Rochester, NY 14642 (USA)
telephone: +1-585-275-9994; fax +1-585 756 4133
This work was partially supported by National Institutes of Health grants CA71570 and CA55639 (to C.C.), and National Science Council (NSC92-2311-B-259-005) (to H.J.L., Taiwan).
Received 15 September 2003;
manuscript accepted 1 October 2003.
Number of Print Pages : 3
Number of Figures : 1, Number of Tables : 0, Number of References : 30
Cytogenetic and Genome Research
Formerly ‘Cytogenetics and Cell Genetics’
Vol. 103, No. 3-4, Year 2003 (Cover Date: 2003)
Journal Editor: H.P. Klinger, Bronx, N.Y.; M. Schmid, Würzburg
ISSN: 1424–8581 (print), 1424–859X (Online)
For additional information: http://www.karger.com/journals/cgr