Journal Mobile Options
Table of Contents
Vol. 72, No. 3, 2004
Issue release date: April 2004
Section title: Original Paper
Urol Int 2004;72:189–195
(DOI:10.1159/000077113)

Neoadjuvant Hormone Treatment with Leuprolide Acetate Depot 3.75 mg and Cyproterone Acetate, before Radical Prostatectomy: A Randomized Study

Prezioso D. · Lotti T. · Polito M. · Montironi R.
Urology Clinic, University ‘Federico II’, Naples, Italy

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/15/2002
Accepted: 4/1/2003
Published online: 4/15/2004
Issue release date: April 2004

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 2

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

Abstract

Objectives: To assess the effect of neoadjuvant hormone treatment before radical prostatectomy on: tumor/prostate volume, prostate-specific antigen (PSA) and testosterone levels, surgical margin status and tumor stage, and the ease of surgery following treatment. Methods: Patients with clinically localized prostatic carcinoma were randomized to receive leuprolide acetate depot 3.75 mg once a month for 3 months and cyproterone acetate 300 mg once a week for 3 weeks prior to surgery (group A). A control group of patients had surgery without any pretreatment (group B). Results: 167 patients were evaluated for the efficacy parameters. In group A, 31% of patients had a reduction in tumor/prostate volume following hormone therapy. PSA and testosterone levels were significantly reduced (p = 0.0001) in patients in group A compared to basal values. Centralized histopathological data evaluated in 145 patients (group A and 75 group B) showed that more patients in group B had tumors at stages T3A and T3B than in group A; this difference was close to significance (p = 0.057). Positive surgical margins were more common in group B (60% of patients) compared to group A (39% of patients). Similarly lymph node involvement was more common in group B compared to group A (11 versus 3%). There was little difference between the 2 study groups for the other surgical parameters assessed (ease of dissection, duration of surgery, blood loss). Conclusions: Neoadjuvant hormone therapy before radical prostatectomy has some effects in the treatment of prostate cancer. However, long-term follow-up of patients is needed to assess the impact of this therapy on morbidity and mortality.

© 2004 S. Karger AG, Basel


  

Author Contacts

Prof. Domenico Prezioso
Via Manzoni, 71
IT–80123 Naples (Italy)
Tel. +39 081 7462606, Fax +39 081 5452959
E-Mail dprezioso@libero.it

  

Article Information

Prof. M. Polito and G. Muzzonigro (University of Ancona, Ancona); Prof. G. Anselmo (Ospedale Civile, Treviso); Prof. C. Aragona (Ospedale Margherita, Messina); Prof. E. Bercovich (Policlinico, Sassari); Prof. A.V. Bono (Ospedale di Circolo, Varese); Dr P. Ferrari (Ospedale S. Agostino, Modena); Prof. G. Comeri (Ospedale S. Anna, Como); Prof. E. Cruciani (Ospedale Fatebenefratelli, Roma); Prof. V. Di Santo (Ospedale Regionale Miulli, Acquaviva delle Fonti); Prof. A. Durval (Ospedale Campo di Marte, Lucca); Dr M. Fini (Ospedale Civile, Imola); Dr G. Fontana (Ospedale Civile, Savigliano); Dr L. Galli (Ospedale Fatebenefratelli, Milano); Dr P. Ghiron (Ospedale degli Infermi, Biella); Prof. S. Guazzieri (Ospedale Civile, Belluno); Prof. A. Lotto (Ospedale Civile, Belluno); Prof. A. Manganelli (Ospedale Civile, Siena); Prof. G. Martorana (Università degli Studi, Bologna); Prof. F. Micali (Università di Tor Vergata, Roma); Prof. G. Mobilio (Policlinico Universitario, Verona); Prof. M. Motta (Ospedale Vittorio Emanuele, Catania); Prof. A. Pagliarulo (Università degli Studi, Bari); Dr M. Pietrantuono (Ospedale Gemma de Bonis, Cassino); Dr D. Potenzoni (Ospedale Civile, S. Secondo Parmense); Prof. P. Rigatti (Ospedale S. Raffaele, Milano); Prof. E. Usai (Ospedale S. Trinità, Cagliari).

Received: July 15, 2002
Accepted after revision: March 28, 2003
Number of Print Pages : 7
Number of Figures : 4, Number of Tables : 2, Number of References : 13

  

Publication Details

Urologia Internationalis
Founded 1955 by G. Peter A. Narath and Heinrich Heusser; Continued 1968–1987 by G. Mayor

Vol. 72, No. 3, Year 2004 (Cover Date: Released April 2004)

Journal Editor: D. Hauri, Zürich; M. Porena, Perugia; M.P. Wirth, Dresden
ISSN: 0042–1138 (print), 1423–0399 (Online)

For additional information: http://www.karger.com/uin


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/15/2002
Accepted: 4/1/2003
Published online: 4/15/2004
Issue release date: April 2004

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 2

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.