Frontotemporal Dementia Linked to Chromosome 3Brown J. · Gydesen S. · Johannsen P. · Gade A. · Skibinski G. · Chakrabarti L. · Brun A. · Spillantini M. · Yancopoulou D. · Thusgaard T. · Sorensen A. · Fisher E. · Collinge J.
aDepartment of Neurology, Addenbrooke’s Hospital, Cambridge, bMRC Prion Unit, Institute of Neurology, London, UK; cDepartment of Psychiatry, Central Hospital, Holbaek, dPET Centre, Department of Neurology, Aarhus University Hospitals, Aarhus, eDepartment of Psychology, University of Copenhagen, Rigshospitalet, fInstitute of Medical Genetics, Panum Institute, Copenhagen, Denmark; gDepartment of Pathology, University Hospital of Lund, Lund, Sweden
A large pedigree with autosomal dominant frontotemporal dementia has been identified. Positional cloning has linked the disease gene to the pericentromeric region of chromosome 3. Clinical, neuropsychological, imaging, pathological and molecular genetic data are presented. The genetic mutation responsible for the disease has not been identified.
Dr. J.M. Brown
Department of Neurology, Addenbrooke’s Hospital
Hills Road, Cambridge CB2 2QQ (UK)
Tel. +44 1223 217909, Fax +44 1223 217554
Number of Print Pages : 3
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Dementia and Geriatric Cognitive Disorders
Vol. 17, No. 4, Year 2004 (Cover Date: Released June 2004)
Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/journals/dem